Evidence map›Paper›PMID 8464927›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1993

Dual control of heat shock response: involvement of a constitutive heat shock element-binding factor.

R Y Liu, D Kim, S H Yang, G C Li

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

R Y LiuDepartment of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
D Kim
S H Yang
G C Li
Memorial Sloan Kettering Cancer Center · US

Funding

HYPERTHERMIA AND THE FUNCTIONS OF HSP70R01CA056909 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LI, GLORIA C · 1991 to 2007
$2.0M
FRACTIONATED HYPERTHERMIA AND HEAT SHOCK PROTEINSR01CA031397 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI LI, GLORIA C · 1985 to 1999
–
FRACTIONATED HYPERTHERMIA AND HEAT SHOCK PROTEINSR37CA031397 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI LI, GLORIA C · 1987 to 1994
–
NCI NIH HHS CA-31397NCI NIH HHS CA-56909
6 · The paper itself

Abstract

Heat shock factor (HSF) has been implicated as the key regulatory protein in the heat shock response. Our studies on the response of rodent cells to heat shock or sodium arsenite indicate that a high level of HSF-DNA-binding activity, by itself, is not sufficient for the induction of hsp70 mRNA synthesis; furthermore, a high level of HSF binding is also not necessary for this induction. Analysis of the binding of protein factors to the heat shock element (HSE) in extracts of stressed rodent cells indicates that the regulation of heat shock response involves the heat-inducible HSF and a constitutive HSE-binding factor. Our results also suggest that overexpression of human hsp70 may decrease the level of heat-induced HSF-HSE-binding activity in rat cells.

Indexed as

Promoter Regions, GeneticAnimalsBase SequenceBlotting, NorthernCell LineDNA-Binding ProteinsFibroblastsHeat-Shock ProteinsHot TemperatureHumansKineticsMolecular Sequence DataOligodeoxyribonucleotidesRatsRNA, MessengerTranscription, GeneticDNA-Binding ProteinsHeat-Shock ProteinsOligodeoxyribonucleotidesRNA, Messenger

Identifiers

PMID8464927
PMCPMC46240
OpenAlexW2042955235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.