ArticleProceedings of the National Academy of Sciences of the United States of America1993
Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome.Journal of psychopharmacology (Oxford, England) · 2018Article
- Application of the amniotic fluid metabolome to the study of fetal malformations, using Down syndrome as a specific model.Molecular medicine reports · 2017Article
- Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.American journal of human genetics · 1996Article
- A long-range physical map of human chromosome 21q22.1 band from the YAC continuum.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Molecular mapping of 21 features associated with partial monosomy 21: involvement of the APP-SOD1 region.American journal of human genetics · 1995Article
- Expression and regulation of kainate and AMPA receptors in uncommitted and committed neural progenitors.Neurochemical research · 1995Review
- Genetic mapping of the T lymphocyte-specific transcription factor 7 gene on mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21.Human genetics · 1994Article
- Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis (ALS). Clinical studies in ALS of Guam and experimental studies in deafferented neurons and in beta,beta'-iminodipropionitrile axonopathy.The American journal of pathology · 1994Article
- The positions of 12 simple sequence repeat markers relative to reference loci on mouse chromosome 16.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Receptors for the major excitatory neurotransmitter glutamate may play key roles in neurodegeneration. The mouse Glur-5 gene maps to chromosome 16 between App and Sod-1. The homologous human GLUR5 gene maps to the corresponding region of human chromosome 21, which contains the locus for familial amyotrophic lateral sclerosis. This location, and other features, render GLUR5 a possible candidate gene for familial amyotrophic lateral sclerosis. In addition, dosage imbalance of GLUR5 may have a role in the trisomy 21 (Down syndrome). Further characterization of the murine glutamate receptor family includes mapping of Glur-1 to the same region as neurological mutants spasmodic, shaker-2, tipsy, and vibrator on chromosome 11; Glur-2 near spastic on chromosome 3; Glur-6 near waltzer and Jackson circler on chromosome 10; and Glur-7 near clasper on chromosome 4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.