ArticleProceedings of the National Academy of Sciences of the United States of America1993
Presumptive Renshaw cells contain decreased calbindin during recovery from sciatic nerve lesions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Neuroanatomical and neurochemical atlas of the spiny mouse (Acomys cahirinus) spinal cord.Brain structure & function · 2025Article
- Neurochemical atlas of the rabbit spinal cord.Brain structure & function · 2024Article
- Neurochemical atlas of the cat spinal cord.Frontiers in neuroanatomy · 2022Article
- Characterization of calbindin D28k expressing interneurons in the ventral horn of the mouse spinal cord.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model.Disease models & mechanisms · 2017Article
- Distribution of 28 kDa Calbindin-Immunopositive Neurons in the Cat Spinal Cord.Frontiers in neuroanatomy · 2015Article
- Reduced Renshaw recurrent inhibition after neonatal sciatic nerve crush in rats.Neural plasticity · 2014Article
- Beyond muscular effects: depression of spinal recurrent inhibition after botulinum neurotoxin A.The Journal of physiology · 2013Article
- Glycinergic innervation of motoneurons is deficient in amyotrophic lateral sclerosis mice: a quantitative confocal analysis.The American journal of pathology · 2009Article
- Postnatal phenotype and localization of spinal cord V1 derived interneurons.The Journal of comparative neurology · 2005Article
- Regulation of gephyrin cluster size and inhibitory synaptic currents on Renshaw cells by motor axon excitatory inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Androgen mitigates axotomy-induced decreases in calbindin expression in motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A subpopulation of calbindin-immunoreactive neurons in lamina VII of the spinal cord has been identified by its location as Renshaw cells, the anatomical substrate for recurrent inhibition. The expression of calbindin (28 kDa) in these calbindin-containing rat ventral horn interneurons was studied with immunocytochemistry after sciatic nerve injuries. One week after axotomy calbindin immunoreactivity was strongly reduced on the lesioned side between levels L4 and L6, while calbindin-containing neurons and fibers were still numerous contralaterally and cranially to the lesioned levels. With the progression of regeneration, calbindin-immunoreactive neurons reappeared, reaching a normal distribution 6-8 weeks after the crush. Similar changes could be mimicked by the intramuscular administration of botulinum toxin. These results suggest that calbindin expression in putative Renshaw cells of the spinal cord might be functionally responsive and that maintenance of calbindin expression may depend on the integrity of motoneurons and neuromuscular transmission.
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