ArticleProceedings of the National Academy of Sciences of the United States of America1993
Opioid peptides activate phospholipase D and protein kinase C-epsilon in chicken embryo neuron cultures.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Selenophosphate synthetase 1 (SPS1) is required for the development and selenium homeostasis of central nervous system in chicken (Gallus gallus).Oncotarget · 2017Article
- Priority in selenium homeostasis involves regulation of SepSecS transcription in the chicken brain.PloS one · 2012Article
- Phospholipase D in brain function and Alzheimer's disease.Biochimica et biophysica acta · 2010Review
- Increased response to morphine in mice lacking protein kinase C epsilon.Genes, brain, and behavior · 2007Article
- Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells.Oncogene · 2006Article
- Pathobiology of dynorphins in trauma and disease.Frontiers in bioscience : a journal and virtual library · 2005Review
- Protein kinase C isozymes and addiction.Molecular neurobiology · 2004Review
- Article
- Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.The European journal of neuroscience · 2000Article
- Parallel modulation of receptor for activated C kinase 1 and protein kinase C-alpha and beta isoforms in brains of morphine-treated rats.British journal of pharmacology · 1999Article
- Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits.Molecular and cellular biochemistry · 1998Article
- kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.Brain research · 1996Article
- Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mu-opioid peptide morphiceptin stimulated a Ca(2+)-independent protein kinase C (PKC-epsilon) that is expressed both in embryonic day 6 chicken telencephalon and in derived neuronal cultures. This activation was seen as a 2-fold increase in the activity and level of cytosolic PKC-epsilon and as a transient increase in membrane-associated PKC-epsilon following morphiceptin treatment. Morphiceptin did not activate phospholipase C-mediated phosphatidylinositol hydrolysis but did transiently activate (2- to 3-fold) phospholipase D (PLD), as measured by phosphatidylethanol formation in neuron cultures derived from embryonic day 6 or day 7 cerebral hemispheres. This PLD activation could provide an alternative source of diacylglycerol for the activation of PKC-epsilon and was naloxone-reversible and at least partially blocked by the tyrosine kinase inhibitor herbimycin A. Addition of phorbol 12-myristate 13-acetate stimulated both PLD and PKC-epsilon activities to a greater extent than opioids. The phorbol ester and insulin stimulation of PLD was also blocked by herbimycin. Both morphiceptin (in a naloxone-reversible manner) and phorbol ester increased phosphorylation of similar cytosolic proteins in intact cells, demonstrating a functional role for the PKC-epsilon activation by opioids. This is evidence that opioid receptors are transiently coupled to tyrosine kinase, PLD and PKC-epsilon activation and, by implication, to neuronal cell growth during brain morphogenesis.
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