ArticleProceedings of the National Academy of Sciences of the United States of America1993
Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.Cell metabolism · 2012Article
- Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production.Journal of virology · 2008Article
- MHC class II gene expression is not induced in HPIV3-infected respiratory epithelial cells.Immunologic research · 2004Article
- A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters.Molecular and cellular biology · 2001Article
- Human parainfluenza virus type 3 inhibits gamma interferon-induced major histocompatibility complex class II expression directly and by inducing alpha/beta interferon.Journal of virology · 2001Article
- Somatic cell mutants resistant to retrovirus replication: intracellular blocks during the early stages of infection.Molecular biology of the cell · 1999Article
- Human parainfluenza virus type 3 up-regulates major histocompatibility complex class I and II expression on respiratory epithelial cells: involvement of a STAT1- and CIITA-independent pathway.Journal of virology · 1999Article
- Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta.Molecular and cellular biology · 1999Article
- CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: the invariant chain promoter as a model.Molecular and cellular biology · 1997Article
- Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma.The Journal of experimental medicine · 1995Article
- Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome.The Journal of clinical investigation · 1995Article
- YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes.The Journal of experimental medicine · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using immunoselection, we have isolated 11 independent mutant HT1080 fibrosarcoma cell lines defective in the induction by interferon gamma (IFN-gamma) of the expression of the human leukocyte antigen HLA-DRA. The mutations are recessive and fall into five complementation groups. All the mutants are affected mainly in the expression of major histocompatibility complex class II and invariant-chain genes. Type I mutants (three complementation groups) are completely defective in induction of the invariant-chain and class II HLA-DP, -DQ, -DR, and -DM genes, whereas type II mutants (two complementation groups) induce these genes weakly in response to IFN-gamma, in the order DPB > DRA > invariant chain. The induction by IFN-gamma of the mRNAs for class I, TAP1, LMP7, and 9-27 is partially defective and the induction of the proteins IRF-1 and ICAM-1 is normal in both types of mutants. All the mutants respond normally to IFN-alpha. The mutants are stable and thus can be used to clone the affected genes by reversion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.