ArticleProceedings of the National Academy of Sciences of the United States of America1993
p70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- A monoclonal antibody specific for BK virus large T-antigen (clone BK.T-1) also binds the human Ku autoantigen.Oncogene · 2002Article
- Jun kinase phosphorylates and regulates the DNA binding activity of an octamer binding protein, T-cell factor beta1.Molecular and cellular biology · 1999Article
- Review
- Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids.Nucleic acids research · 1998Review
- The 86-kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells.The Journal of clinical investigation · 1998Article
- Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86.Molecular and cellular biology · 1996Article
- Ku-related antigens are associated with transcriptionally active loci in Chironomus polytene chromosomes.Chromosoma · 1996Article
- A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.The EMBO journal · 1996Article
- Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits.Molecular and cellular biology · 1996Article
- Genetic characterization of transactivation of the human T-cell leukemia virus type 1 promoter: Binding of Tax to Tax-responsive element 1 is mediated by the cyclic AMP-responsive members of the CREB/ATF family of transcription factors.Molecular and cellular biology · 1996Article
- A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Production and characterization of recombinant human Ku antigen.Nucleic acids research · 1994Article
- A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer.Molecular and cellular biology · 1994Article
- A novel POU domain protein which binds to the T-cell receptor beta enhancer.Molecular and cellular biology · 1993Article
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The p70 (Ku) autoantigen has been described as a nonhistone nuclear protein recognized by antibodies from lupus patients. In our studies on the regulation of T-cell receptor (TCR) beta-chain gene expression we have identified the p70 lupus autoantigen as a DNA-binding protein that binds the enhancer of the TCR beta-chain gene. This enhancer is essential for expression of the TCR beta gene. The core TCR beta enhancer contains the E3 motif, which we show here is essential for enhancer activity. The protection of the E3 motif in T cells and the marked reduction in enhancer activity when the E3 motif is mutated underline its physiological importance in regulating beta enhancer activity. The p70 lupus autoantigen gene was identified by screening T-cell lambda gt11 libraries with an E3 probe. The gene encodes a protein which binds the E3 motif in a sequence-specific manner. The identification of a 70-kDa protein as a major E3-binding protein by UV crosslinking is consistent with the conclusion that the p70 lupus autoantigen binds the beta enhancer. Finally, we have shown that T-cell nuclear proteins which bind the E3 motif bear p70 (Ku) lupus autoantigenic determinants. Together these data suggest that the p70 autoantigen binds a critical motif in the beta enhancer and probably regulates TCR beta gene expression.
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