ArticleNucleic acids research1993
The sequence of 28S ribosomal RNA varies within and between human cell lines.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Assessing Human Ribosomal DNA Variation and Its Association With Phenotypic Outcomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Ribosome Structural Changes Dynamically Affect Ribosome Function.International journal of molecular sciences · 2024Review
- Article
- Short arms of human acrocentric chromosomes and the completion of the human genome sequence.Genome research · 2022Article
- Variability of Human rDNA.Cells · 2021Review
- VELCRO-IP RNA-seq reveals ribosome expansion segment function in translation genome-wide.Cell reports · 2021Article
- Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments.Molecular cell · 2020Article
- Decoding the Function of Expansion Segments in Ribosomes.Molecular cell · 2018Article
- Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing.Nucleic acids research · 2018Article
- Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.Science advances · 2018Article
- Expression of distinct maternal and somatic 5.8S, 18S, and 28S rRNA types during zebrafish development.RNA (New York, N.Y.) · 2017Article
- Article
- Cleavage of rRNA ensures translational cessation in sperm at fertilization.Molecular human reproduction · 2011Article
- Molecular species identification of Central European ground beetles (Coleoptera: Carabidae) using nuclear rDNA expansion segments and DNA barcodes.Frontiers in zoology · 2010Article
- Article
- The ribosome filter hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2002Review
- Novel processing in a mammalian nuclear 28S pre-rRNA: tissue-specific elimination of an 'intron' bearing a hidden break site.The EMBO journal · 1999Article
- Human ribosomal RNA variants from a single individual and their expression in different tissues.Nucleic acids research · 1996Article
- Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis.Experientia · 1996Review
- Studies of the inheritance of human ribosomal DNA variants detected in two-dimensional separations of genomic restriction fragments.Genetics · 1996Article
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2 authors.
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Abstract
The primary structure of 28S ribosomal RNA constitutes a conserved core which is similar among most 23S-like rRNAs and expansion segments which occur at specific positions in the sequence. The expansion segments account for most of the size difference between prokaryotic (archaeal and eubacterial) and eukaryotic rRNAs and they exhibit a sequence variation which is unique among rRNAs. We have investigated the sequence variation of one of the expansion segments, V8, by sequencing a total of 111 V8 segments from 9 different human cell lines and tissues and have found 35 different variants. The variation occur mainly at two 'hot spots' which are separated by 170 nucleotides in the primary sequence but are neighbours in the secondary structure. The sequence of V8 segments varies both within and between human cell lines and tissues. The implications for the evolution of the eukaryotic 28S rRNA are discussed together with possible functions of the expansion segments. We also present a secondary structure model for the V8 segment based on comparative sequence analysis and chemical and enzymatic foot printing.
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