ArticleNucleic acids research1993
Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Primate protein-ligand interfaces exhibit significant conservation and unveil human-specific evolutionary drivers.PLoS computational biology · 2023Article
- Expression pattern of ZNF33B in bovine ovaries and the effect of its polymorphism on superovulation traits.Archives animal breeding · 2022Article
- Characterization of genome-wide segmental duplications reveals a common genomic feature of association with immunity among domestic animals.BMC genomics · 2017Article
- Gene-based analysis identified the gene ZNF248 is associated with late-onset asthma in African Americans.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
- Article
- Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes.Genome research · 2006Article
- Large-scale variation among human and great ape genomes determined by array comparative genomic hybridization.Genome research · 2003Article
- Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p.Genome research · 2003Article
- Human gene mutation in pathology and evolution.Journal of inherited metabolic disease · 2002Review
- An integrated physical map for the short arm of human chromosome 5.Genome research · 1999Article
- From repression domains to designer zinc finger proteins: a novel strategy of intracellular immunization against HIV.Gene expression · 1996Article
- Ordering of markers in the pericentromeric region of chromosome 10.Human genetics · 1995Article
- Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes.Human genetics · 1995Article
- A rearrangement on chromosome 5 of an expressed human beta-glucuronidase pseudogene.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- A multiple interval physical map of the pericentromeric region of human chromosome 10.Human genetics · 1994Article
- The organisation of repetitive sequences in the pericentromeric region of human chromosome 10.Nucleic acids research · 1993Article
- Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19.Human genetics · 1993Article
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9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Two related zinc finger (ZNF) gene clusters from the pericentromeric region of human chromosome 10, defined by cDNAs of the KOX series, have been cloned in yeast artificial chromosomes (YACs). The two clusters evolved by duplication of an ancestral gene cluster before the divergence of the human and great ape lineages. Included in cluster A are the ZNF gene sequences ZNF11A, ZNF33A, and ZNF37A, while cluster B comprises the related sequences ZNF11B, ZNF33B and ZNF37B. Genes from both clusters are expressed: cDNAs KOX2, KOX31 and KOX21 derive from ZNF11B, ZNF33A and ZNF37A, respectively. Further YACs have been isolated which link ZNF11A and ZNF33A to another gene, ZNF25, defined by cDNA clone KOX19. Therefore ZNF25 also forms part of cluster A, but has no counterpart in cluster B. Surprisingly, the KOX ZNF gene clusters are located on opposite sides of the centromere: cluster A maps to 10p11.2, while cluster B is in 10q11.2. This suggests the occurrence during primate evolution of a previously undescribed pericentric inversion subsequent to the cluster duplication. The evolution of this subset of KOX ZNF genes has therefore involved three types of genetic event: local gene duplication, gene cluster duplication, and chromosome rearrangement.
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