ArticleNucleic acids research1993
Evolutionary conservation of excision repair in Schizosaccharomyces pombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Article
- Postreplication repair and PCNA modification in Schizosaccharomyces pombe.Molecular biology of the cell · 2006Article
- The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Molecular and cellular biology · 2006Article
- Brc1-mediated DNA repair and damage tolerance.Genetics · 2005Article
- DNA repair functions that control sensitivity to topoisomerase-targeting drugs.Eukaryotic cell · 2004Article
- A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe.Molecular and cellular biology · 2000Article
- Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe.Journal of bacteriology · 2000Article
- Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis.Molecular and cellular biology · 1999Article
- Rad18 is required for DNA repair and checkpoint responses in fission yeast.Molecular biology of the cell · 1999Article
- Comparison of the 5' nuclease activities of taq DNA polymerase and its isolated nuclease domain.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Saccharomyces cerevisiae exonuclease-1 plays a role in UV resistance that is distinct from nucleotide excision repair.Nucleic acids research · 1998Article
- Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance.Molecular and cellular biology · 1997Article
- Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.Journal of virology · 1997Article
- Functional analysis of point mutations in human flap endonuclease-1 active site.Nucleic acids research · 1997Article
- Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).The EMBO journal · 1997Article
- Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.Nucleic acids research · 1997Article
- Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.Nucleic acids research · 1997Article
- Molecular cloning and structural analysis of the functional mouse genomic XPG gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.Molecular & general genetics : MGG · 1996Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells mutated at the rad13 locus in the fission yeast, Schizosaccharomyces pombe are deficient in excision-repair of UV damage. We have cloned the S.pombe rad13 gene by its ability to complement the UV sensitivity of a rad13 mutant. The gene is not essential for cell proliferation. Sequence analysis of the cloned gene revealed an open reading-frame of 1113 amino acids with structural homology to the RAD2 gene of the distantly related Saccharomyces cerevisiae. The sequence similarity is confined to three domains, two close to the N-terminus of the encoded protein, the third being close to the C-terminus. The central region of about 500 amino acids shows little similarity between the two organisms. The first and third domains are also found in a related yet distinct pair of homologous S.pombe/S.cerevisiae DNA repair genes (rad2/YKL510), which have only a very short region between these two conserved domains. Using the polymerase chain reaction with degenerate primers, we have isolated fragments from a gene homologous to rad13/RAD2 from Aspergillus nidulans. These findings define new functional domains involved in excision-repair, as well as identifying a conserved family of genes related to RAD2.
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