ArticleNucleic acids research1993
Comparative analysis of the locus control region of the rabbit beta-like gene cluster: HS3 increases transient expression of an embryonic epsilon-globin gene.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Evolution of hemoglobin and its genes.Cold Spring Harbor perspectives in medicine · 2012Article
- Genomic approaches towards finding cis-regulatory modules in animals.Nature reviews. Genetics · 2012Review
- Article
- Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control region.Nucleic acids research · 2002Article
- Enhancement of beta-globin locus control region-mediated transactivation by mitogen-activated protein kinases through stochastic and graded mechanisms.Molecular and cellular biology · 1999Article
- Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Synergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Sequences within and flanking hypersensitive sites 3 and 2 of the beta-globin locus control region required for synergistic versus additive interaction with the epsilon-globin gene promoter.Nucleic acids research · 1996Article
- Reduction of two functional gamma-globin genes to one: an evolutionary trend in New World monkeys (infraorder Platyrrhini).Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.Molecular and cellular biology · 1996Article
- A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction.Molecular and cellular biology · 1996Article
- Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells.Molecular and cellular biology · 1996Article
- A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.The EMBO journal · 1994Article
- Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expression.Nucleic acids research · 1994Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The rabbit homolog to the locus control region (LCR) of the human beta-like globin gene cluster was isolated, and long segments containing the DNase I hypersensitive sites (HS) were sequenced. The order and spacing of HS4, HS3, HS2 and HS1 are conserved between rabbit and human. Alignment of these sequences with their homologs from human, goat, and mouse shows that very long segments of DNA match between species, for over a thousand base pairs on either side of the previously identified functional cores, indicating that some important functions are found outside the cores. The activity of rabbit HS2 and HS3 was tested by attaching each to a novel reporter gene constructed by inserting the luciferase coding region into the rabbit epsilon-globin gene. In contrast to previous reports showing no effect of human or mouse HS3 on transient expression, both the rabbit HS2 and HS3 DNA fragments separately increased transient expression from the epsilon-luciferase hybrid gene and expression from stably integrated constructs in K562 erythroleukemia cells.
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