ArticleImmunogenetics1993
Cloning of the beta 2-microglobulin gene in the zebrafish.
Article in Immunogenetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 77 citations in OpenAlex.
- Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells.Science (New York, N.Y.) · 2024Article
- Article
- Methodological considerations for aqueous environmental RNA collection, preservation, and extraction.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023Article
- The Mechanism of β2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish.iScience · 2020Article
- Review
- DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish.PloS one · 2012Article
- Primordial linkage of β2-microglobulin to the MHC.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Characterization of the functional domain of β2-microglobulin from the Asian seabass, Lates calcarifer.PloS one · 2010Article
- Crystal structure of a bony fish beta2-microglobulin: insights into the evolutionary origin of immunoglobulin superfamily constant molecules.The Journal of biological chemistry · 2010Article
- Molecular characterization and expression analysis of beta2-microglobulin in large yellow croaker Pseudosciaena crocea.Molecular biology reports · 2009Article
- Analysis of genomic and expressed major histocompatibility class Ia and class II genes in a hexaploid Lake Tana African 'large' barb individual (Barbus intermedius).Immunogenetics · 2004Article
- Article
- The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Molecular cloning and linkage analysis of the Japanese medaka fish complement Bf/C2 gene.Immunogenetics · 1996Article
- Identification and characterization of a new major histocompatibility complex class I gene in carp (Cyprinus carpio L.).Immunogenetics · 1996Article
- "Both man & bird & beast": comparative organization of MHC genes.Immunogenetics · 1995Review
- Cloning and characterization of class I Mhc genes of the zebrafish, Brachydanio rerio.Immunogenetics · 1995Article
- The conundrum of nonclassical major histocompatibility complex genes.Proceedings of the National Academy of Sciences of the United States of America · 1994Review
- Isolation and characterization of major histocompatibility complex class IIB genes from the nurse shark.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Isolation of a clone for pig beta 2-microglobulin cDNA.Immunogenetics · 1993Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The beta 2-microglobulin (beta 2m) is a protein found in the serum in a free form and on the cell surface in a form noncovalently associated with the alpha chain of the class I major histocompatibility complex (Mhc) molecules. In mammals, the beta 2m-encoding gene (B2m) is found on a chromosome different from the Mhc proper. We have isolated and characterized the B2m gene of the zebrafish, Brachydanio rerio, family Cyprinidae. We obtained both cDNA and genomic clones of the Brre-B2m gene. The cDNA clones contained the entire coding sequence, the entire 3' untranslated (UT) region, and at least part of the 5'UT region. The genomic clone contained the entire Brre-B2m gene. The coding sequence specifies 97 amino acid residues of the mature protein so that the zebrafish beta 2m is two residues shorter than human and one residue shorter than cattle, fowl, or turkey beta 2m (codons at positions 85 and 86 have been deleted in the Brre-B2m gene). The amino acid and nucleotide sequence similarities between zebrafish and human beta 2m (B2m) are 45% and 59%, respectively. Approximately 24% of the positions are invariant and an additional 9% show only conservative substitutions in comparisons which include all known beta 2m sequences (fish, avian, and mammalian). Most of the conserved positions are in the beta strands (some 47% of the beta-strand positions are conserved in the three vertebrate classes). The Brre-B2m gene consists of four exons separated by three introns. All of the introns are considerably shorter than the corresponding introns in the mammalian B2m genes. The coding sequences of the cDNA and the genomic clones are almost identical but the sequences of the 3'UT regions differ at 1.7% of the sites, suggesting that the genes borne by these clones might have diverged at least 0.7 million years (my) ago. In contrast to the human B2m gene, the Brre-B2m gene shows no bias in the distribution of the CpG dinucleotides: the dinucleotides are distributed evenly along the entire available sequence. The haploid genome of the zebrafish contains only one copy of the B2m gene.
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