ArticleGenetics1993
A genetic analysis of the stoned locus and its interaction with dunce, shibire and Suppressor of stoned variants of Drosophila melanogaster.
Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Modeling AP2M1 developmental and epileptic encephalopathy in Drosophila.Disease models & mechanisms · 2025Article
- UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans.PloS one · 2012Article
- Ca2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1.PloS one · 2012Article
- Drosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin.Traffic (Copenhagen, Denmark) · 2010Article
- Article
- Molecular and genetic characterization of the interactions between the Drosophila stoned-B protein and DAP-160 (intersectin).The Biochemical journal · 2005Article
- Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.The Journal of cell biology · 2001Article
- Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- A product of the Drosophila stoned locus regulates neurotransmitter release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- The stoned locus of Drosophila melanogaster produces a dicistronic transcript and encodes two distinct polypeptides.Genetics · 1996Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic complementation patterns of both behavioral and lethal alleles at the stoned locus have been characterized. Mosaic analysis of a stoned lethal allele suggests that stoned functions either in the nervous system or in both the nervous system and musculature, but is not required for gross neural development. The behavioral alleles stnts and stnC, appear to be defective in a diametrically opposite sense, show interallelic complementation, and indicate distinct roles for the stoned gene product in the visual system and in motor coordination. A number of other neurological mutations have been investigated for their possible interaction with the viable stoned alleles. Mutations at two loci, dunce and shibire, act synergistically with the stnts mutations to cause lethality, but fail to interact with stnC. A third variant (Suppressor of stoned) has been identified which can suppress the debilitation associated with the stnts mutations. These data, together with a previously identified interaction between the stnts and tan mutants, indicate a central role for the stoned gene product in neuronal function, and suggests that the stoned gene product interacts, either directly or indirectly, with the neural cAMP second messenger system, with the synaptic membrane recycling pathway via dynamin, and with biogenic amine metabolism.
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