ArticleBMJ (Clinical research ed.)1993
Association of low birth weight with beta cell function in the adult first degree relatives of non-insulin dependent diabetic subjects.
Article in BMJ (Clinical research ed.), 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 81 citations in OpenAlex.
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
- Case of type 2 diabetes possibly caused by excessive accumulation of visceral fat in a child born small-for-gestational age.Journal of diabetes investigation · 2020Article
- Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease: Addressing the Barker Hypothesis With Mendelian Randomization.Circulation. Genomic and precision medicine · 2018Article
- The impact of IUGR on pancreatic islet development and β-cell function.The Journal of endocrinology · 2017Review
- Body composition and susceptibility to type 2 diabetes: an evolutionary perspective.European journal of clinical nutrition · 2017Review
- The Elevated Susceptibility to Diabetes in India: An Evolutionary Perspective.Frontiers in public health · 2016Review
- Birth weight and risk factors for cardiovascular disease and type 2 diabetes in US children and adolescents: 10 year results from NHANES.Maternal and child health journal · 2014Article
- SGA children with moderate catch-up growth are showing the impaired insulin secretion at the age of 4.PloS one · 2014Article
- Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes.Diabetologia · 2010Article
- Mechanisms of developmental programming of the metabolic syndrome and related disorders.World journal of diabetes · 2010Article
- Evaluation of neonatally-induced mild diabetes in rats: Maternal and fetal repercussions.Diabetology & metabolic syndrome · 2010Article
- An investigation into genetic contribution to the relationship between insulin resistance and birth weight.International journal of diabetes in developing countries · 2009Article
- Regulation of skeletal muscle PPAR delta mRNA expression in twins.The Journal of physiology · 2007Article
- Does zygosity influence the metabolic profile of twins? A population based cross sectional study.BMJ (Clinical research ed.) · 1999Article
- Diabetes.BMJ (Clinical research ed.) · 1998Review
- Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years.BMJ (Clinical research ed.) · 1996Article
- Use of specific immunoradiometric assay to determine preterm neonatal insulin-glucose relations.Archives of disease in childhood. Fetal and neonatal edition · 1995Article
- New concepts in diabetes mellitus. I: Treatment, pregnancy and aetiology.Postgraduate medical journal · 1994Review
- Relation between birth weight at term and systolic blood pressure in adolescence.BMJ (Clinical research ed.) · 1994Article
- Thinness at birth and insulin resistance in adult life.Diabetologia · 1994Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the relation between birth weight and beta cell function in the first degree relatives of non-insulin dependent diabetic subjects.
designCross sectional study of 101 adults of known birth weight from 47 families which had at least one member with non-insulin dependent diabetes. SUBJECTS: 101 white adults aged mean 43 (SD 7) years.
settingOxfordshire, England.
main outcome measuresGlucose tolerance was measured by continuous infusion glucose tolerance test. beta cell function and insulin sensitivity were calculated from the fasting plasma glucose and insulin concentrations with homeostasis model assessment. beta cell function was standardised to allow for the confounding effects of age and obesity.
resultsTwenty seven subjects had non-insulin dependent diabetes, 32 had impaired glucose tolerance, and 42 were normoglycaemic. Birth weight correlated with the beta cell function of the complete cohort (rs = 0.29, p = 0.005), the non-insulin dependent diabetic subjects (rs = 0.50, p = 0.023), and the non-diabetic subjects (rs = 0.29, p = 0.013). The non-insulin dependent diabetic (n = 27) and the non-diabetic (n = 74) subjects had similar mean (inter-quartile range) centile birth weight 50% (19%-91%), and 53% (30%-75%) respectively. Non-insulin dependent diabetic subjects had significantly lower beta function than the non-diabetic subjects: 69% (48%-83%) v 97% (86%-120%), p < 0.001.
conclusionsThe cause of the association between low birth weight and reduced beta cell function in adult life is uncertain. Impaired beta cell function in non-insulin dependent diabetic subjects was not accounted for by low birth weight, and genetic or environmental factors are likely to be necessary for development of diabetes.
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