ArticleAmerican journal of human genetics1993
THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.
Article in American journal of human genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- Review
- A TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy.Science signaling · 2016Article
- UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens.Oncology letters · 2016Article
- Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.American journal of human genetics · 1998Article
- Evidence for genetic anticipation in non-Mendelian diseases.American journal of human genetics · 1996Article
- Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families.American journal of human genetics · 1995Article
- A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase.Human genetics · 1995Article
- Biological indices in the assessment of breast cancer.Clinical molecular pathology · 1995Article
- Molecular genetics of familial breast-ovarian cancer.Journal of clinical pathology · 1995Review
- The human breast and the ancestral reproductive cycle : A preliminary inquiry into breast cancer etiology.Human nature (Hawthorne, N.Y.) · 1995Article
- A human SHC-related sequence maps to chromosome 17, the SHC gene maps to chromosome 1.Human genetics · 1995Article
- Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region.British journal of cancer · 1995Article
- Transcript identification in the BRCA1 candidate region.Breast cancer research and treatment · 1995Review
- An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.American journal of human genetics · 1995Article
- Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.American journal of human genetics · 1995Article
- Linkage analysis of BRCA1 in Japanese breast cancer families.Japanese journal of cancer research : Gann · 1994Article
- A common region of deletion on chromosome 17q in both sporadic and familial epithelial ovarian tumors distal to BRCA1.American journal of human genetics · 1994Article
- The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer.The EMBO journal · 1994Article
- A radiation hybrid map of the BRCA1 region.American journal of human genetics · 1994Article
- Genetic mapping of the BRCA1 region on chromosome 17q21.American journal of human genetics · 1994Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were developed within the locus for thyroid hormone receptor alpha (THRA1) and for several anonymous sequences at chromosome 17q12-q21. The THRA1 polymorphism is a dinucleotide repeat with 10 alleles and heterozygosity.79. Gene mapping in extended families with inherited, early-onset breast and ovarian cancer indicates that BRCA1 is distal to THRA1 and proximal to D17S183 (SCG43), an interval of < 4 cM. This locale excludes HER2, THRA1, WNT3, HOX2, NGFR, PHB, COLIA1, NME1, and NME2 as candidates for BRCA1 but does not exclude RARA or EDH17B. Resolving the remaining recombination events in these families by new polymorphisms in the THRA1-D17S183 interval will facilitate positional cloning of the breast-ovarian cancer gene on chromosome 17q12-q21.
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8460637PMC1682071W1939367625What OpenQuestion holds
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