ArticleThe Journal of experimental medicine1993
Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia.
Article in The Journal of experimental medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- IL-7 is expressed in malignant mesothelioma and has a prognostic value.Molecular oncology · 2022Article
- Flip the coin: IL-7 and IL-7R in health and disease.Nature immunology · 2019Review
- IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update.Advances in biological regulation · 2019Review
- Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells.Clinical and experimental immunology · 2011Article
- Increased (6 exon) interleukin-7 production after M. tuberculosis infection and soluble interleukin-7 receptor expression in lung tissue.Genes and immunity · 2011Article
- [The expressions of IL-7 and IL-7R and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Article
- Expression analysis and functional activity of interleukin-7 splice variants.Genes and immunity · 2009Article
- Article
- Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia.Arthritis research & therapy · 2005Article
- Role of beta2 integrins in the prevention of apoptosis induction in chronic lymphocytic leukemia B cells.Leukemia · 2000Article
- Modulation of tumoricidal function in alveolar macrophages from lung cancer patients by interleukin-6.Cancer immunology, immunotherapy : CII · 1997Article
- Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Frequent expression of IL-7 gene transcripts in tumor cells of classical Hodgkin's disease.The American journal of pathology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of expression of interleukin 7 (IL-7) mRNA is aberrant in the leukemic subset of cells of chronic lymphocytic leukemia (CLL) patients. The entire coding sequence for IL-7 as well as an alternatively spliced IL-7 mRNA are transcribed in these leukemic cells. No IL-7 mRNA expression is detected in fresh peripheral blood mononuclear cells from normal individuals. Furthermore, the "normal" nonleukemic subsets of cells isolated from the same CLL patients also do not express IL-7 mRNA. The only subset of cells in which IL-7 mRNA is detected is the one that contains the leukemic cells themselves. The polymerase chain reaction was used to examine cytokine expression, and flow cytometry was used to purify the various subsets of peripheral blood mononuclear cells examined in these studies, as well as to examine IL-7 receptor expression. A proportion of the cells from the CLL patients express receptors that are capable of binding IL-7, whereas T cell-depleted normal cell preparations do not express receptors for IL-7 that are detectable with IL-7 fluorokines. The IL-7 receptor-bearing cells in CLL patients include a portion of leukemic cells and a fraction of the T cells, as well as some non-T, non-B cells. These findings suggest that IL-7 and IL-7 receptor expression in CLL may be relevant not only to growth regulation of the leukemic cells but to the immunological abnormalities that occur in the disease as well, possibly via the induction of inappropriate immune activity of IL-7 receptor-bearing cells.
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