Potential role for scavenger receptors of human monocytes in the killing of Schistosoma mansoni.

X Xu, H G Remold, J P Caulfield

Open access · greenAbstract read

In one paragraph

Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.7field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1.PLoS neglected tropical diseases · 2014
Article
Dextran sulfate can act as an artificial receptor to mediate a type-specific herpes simplex virus infection via glycoprotein B.Journal of virology · 1997
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

X XuDepartment of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts.

H G Remold

J P Caulfield

Funding

STUDIES ON CELLULAR IMMUNITYR01AI022532 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAVID, JOHN R · 1985 to 1997

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S. MANSONI: IMMUNE INDUCED SURFACE CHANGESR01AI023083 · NIAID · SYNTEX (USA), INC.-RESEARCH DIVISION · PI CAULFIELD, JOHN P · 1989 to 1994

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S MANSONI: IMMUNE INDUCED SURFACE CHANGESR22AI023083 · NIAID · SYNTEX (USA), INC.-RESEARCH DIVISION · PI CAULFIELD, JOHN P · 1985 to 1991

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NIAID NIH HHS AI-22532NIAID NIH HHS AI-23083

6 · The paper itself

Abstract

Human low-density lipoproteins (LDL) bind specifically and saturably to the surface of the trematode parasite, Schistosoma mansoni, in vitro. Here we have tested whether human monocytes process the bound LDL. Monocytes obtained by leukapheresis generate H2O2, kill schistosomula, and were seen here endocytosing fluorescently labeled human LDL that was bound to the surface of the parasites. Compounds known to inhibit uptake of LDL via the scavenger receptor, namely, acetylated LDL, polyinosinic acid, dextran sulfate, fucoidan, and polyvinyl sulfate, inhibited both endocytosis of LDL and cell-mediated killing. Non-functional analogs of these inhibitors, namely, polycytidylic acid and dextran, did not inhibit either endocytosis or killing. Monocytes obtained from whole blood after venipuncture neither killed the parasite nor endocytosed LDL from the worm surface. Thus, human monocyte killing of schistosomula may involve removal of LDL from the parasite surface via scavenger receptors.

Indexed as

Membrane ProteinsReceptors, LipoproteinAnimalsCarbocyaninesEndocytosisFluorescent DyesHumansLipoproteins, LDLMonocytesReceptors, ImmunologicReceptors, ScavengerScavenger Receptors, Class BSchistosoma mansoni3,3'-dioctadecylindocarbocyanineCarbocyaninesFluorescent DyesLipoproteins, LDLMembrane ProteinsReceptors, ImmunologicReceptors, LipoproteinReceptors, ScavengerScarb1 protein, mouseScavenger Receptors, Class B

Identifiers

PMID8456931

PMCPMC1886792

OpenAlexW64239948

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.