ArticleMolecular and cellular biology1993
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 231 citations in OpenAlex.
- Fortilin binds and stabilizes MEF2C, activates it through phosphorylation, and drives transcription of the cell structural and survival protein CTNNA3.The Journal of biological chemistry · 2026Article
- The muscle specific MEF2Dα2 isoform promotes muscle ketolysis and running capacity in mice.EMBO reports · 2025Article
- Spatiotemporal 3D chromatin organization across multiple brain regions during human fetal development.Cell discovery · 2025Article
- The MEF2A transcription factor interactome in cardiomyocytes.Cell death & disease · 2023Article
- Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between subgroups.BMC cancer · 2018Article
- Review
- PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.Stem cell research & therapy · 2018Article
- miR-487b-3p Suppresses the Proliferation and Differentiation of Myoblasts by Targeting IRS1 in Skeletal Muscle Myogenesis.International journal of biological sciences · 2018Article
- HDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription.Molecules and cells · 2017Article
- Review
- A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells.Cell death & disease · 2015Article
- Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas.Virchows Archiv : an international journal of pathology · 2015Article
- The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase.Molecular and cellular biology · 2015Article
- Alternative splicing of MEF2C pre-mRNA controls its activity in normal myogenesis and promotes tumorigenicity in rhabdomyosarcoma cells.The Journal of biological chemistry · 2015Article
- Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response.Nucleus (Austin, Tex.) · 2015Review
- Phosphorylation-dependent degradation of MEF2C contributes to regulate G2/M transition.Cell cycle (Georgetown, Tex.) · 2015Article
- Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb.Biochimica et biophysica acta · 2014Article
- Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization.Autophagy · 2014Article
- AMPK agonist AICAR improves cognition and motor coordination in young and aged mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Article
32 more citing papers are in PubMed but not listed here.
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myocyte enhancer-binding factor 2 (MEF2) site is an essential element of many muscle-specific enhancers and promoters that binds nuclear proteins from muscle and brain. Recently, we have cloned a family of MEF2 transcription factors produced by two genes that, at the mRNA level, are broadly expressed and produce tissue-specific isoforms by posttranscriptional processes (Y.-T. Yu, R. E. Breitbart, L. B. Smoot, Y. Lee, V. Mahdavi, and B. Nadal-Ginard, Genes Dev. 6:1783-1798, 1992). Here, we report the isolation and functional characterization of cDNA clones encoding four MEF2 factors derived from a separate gene that we have named hMEF2C. In contrast to those of the previously reported genes, the transcripts of the hMEF2C gene are restricted to skeletal muscle and brain. One of the alternate exons is exclusively present in brain transcripts. The products of this gene have DNA-binding and trans-activating activities indistinguishable from those of the previously reported MEF2 factors. The hMEF2C gene is induced late during myogenic differentiation, and its expression is limited to a subset of cortical neurons. The potential targets for this transcription factor in a subset of neurons are not known at this time. The strict tissue-specific pattern of expression of hMEF2C in comparison with the more ubiquitous expression of other MEF2 genes suggests a different mode of regulation and a potentially important role of hMEF2C factors in myogenesis and neurogenesis.
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