ArticleMolecular and cellular biology1993
Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 124 citations in OpenAlex.
- Article
- LINC01526 Promotes Proliferation and Metastasis of Gastric Cancer by Interacting with TARBP2 to Induce GNG7 mRNA Decay.Cancers · 2022Article
- Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling.The Biochemical journal · 2021Article
- Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro.PloS one · 2016Article
- Trbp regulates heart function through microRNA-mediated Sox6 repression.Nature genetics · 2015Article
- Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control.Biomolecules · 2015Review
- Article
- HIV-1 RRE RNA acts as an RNA silencing suppressor by competing with TRBP-bound siRNAs.RNA biology · 2015Article
- Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.Nature · 2014Article
- Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.The Journal of biological chemistry · 2014Article
- GraphProt: modeling binding preferences of RNA-binding proteins.Genome biology · 2014Article
- ATP-independent diffusion of double-stranded RNA binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- The multiple functions of TRBP, at the hub of cell responses to viruses, stress, and cancer.Microbiology and molecular biology reviews : MMBR · 2012Review
- TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response.PloS one · 2012Article
- A proteomic study of TAR-RNA binding protein (TRBP)-associated factors.Cell & bioscience · 2011Article
- Review
- Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein.Protein science : a publication of the Protein Society · 2011Article
- Substrate-specific kinetics of Dicer-catalyzed RNA processing.Journal of molecular biology · 2010Article
- Identification of small molecules that suppress microRNA function and reverse tumorigenesis.The Journal of biological chemistry · 2010Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TRBP is a human cellular protein that binds the human immunodeficiency virus type 1 TAR RNA. Here, we show that the intact presence of amino acids 247 to 267 in TRBP correlates with its ability to bind RNA. This region contains a lysine- and arginine-rich motif, KKLAKRNAAAKMLLRVHTVPLDAR. A 24-amino-acid synthetic peptide (TR1) of this sequence bound TAR RNA with affinities similar to that of the entire TRBP, thus suggesting that this short motif contains a sufficient RNA-binding activity. Using RNA probe-shift analysis, we determined that TR1 does not bind all double-stranded RNAs but prefers TAR and other double-stranded RNAs with G+C-rich characteristics. Immunoprecipitation of TRBP from human immunodeficiency virus type 1-infected T lymphocytes recovered TAR RNA. This is consistent with a TRBP-TAR ribonucleoprotein during viral infection. Computer alignment revealed that TR1 is highly homologous to the RNA-binding domain of human P1/dsI protein kinase and two regions within Drosophila Staufen. We suggest that these proteins are related by virtue of sharing a common RNA-binding moiety.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.