ArticleInfection and immunity1993
Gamma interferon cooperates with lipopolysaccharide to activate mouse splenic macrophages to an antihistoplasma state.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
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- Article
- Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis.Journal of microbiology (Seoul, Korea) · 2016Review
- Histoplasma capsulatum, lung infection and immunity.Future microbiology · 2015Review
- Potent anti-inflammatory activity of pyrenocine A isolated from the marine-derived fungus Penicillium paxilli Ma(G)K.Mediators of inflammation · 2014Article
- Characterization of murine macrophages from bone marrow, spleen and peritoneum.BMC immunology · 2013Article
- Celecoxib improves host defense through prostaglandin inhibition during Histoplasma capsulatum infection.Mediators of inflammation · 2013Article
- CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Histoplasma capsulatum proteome response to decreased iron availability.Proteome science · 2008Article
- A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages.Eukaryotic cell · 2008Article
- Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis.Infection and immunity · 2004Article
- Nitric oxide synthase expression in macrophages of Histoplasma capsulatum-infected mice is associated with splenocyte apoptosis and unresponsiveness.Infection and immunity · 1998Article
- Evolution of the primary immune response to Histoplasma capsulatum in murine lung.Infection and immunity · 1998Article
- Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice.Infection and immunity · 1997Article
- Virulence factors of medically important fungi.Clinical microbiology reviews · 1996Review
- Roles for tumor necrosis factor alpha and nitric oxide in resistance of rat alveolar macrophages to Legionella pneumophila.Infection and immunity · 1996Article
- Inhibition of growth of Histoplasma capsulatum yeast cells in human macrophages by the iron chelator VUF 8514 and comparison of VUF 8514 with deferoxamine.Antimicrobial agents and chemotherapy · 1995Article
- Impaired responsiveness to gamma interferon of macrophages infected with lymphocytic choriomeningitis virus clone 13: susceptibility to histoplasmosis.Infection and immunity · 1995Article
- Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron(III).Infection and immunity · 1994Article
- Antihistoplasma effect of activated mouse splenic macrophages involves production of reactive nitrogen intermediates.Infection and immunity · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Inhibition of the intracellular growth of Histoplasma capsulatum by murine resident red pulp splenic macrophages was examined. Splenic macrophages, unlike resident peritoneal macrophages, required a prolonged preincubation (18 h) with recombinant murine gamma interferon (rMuIFN-gamma) for activation. To be fully activated, the splenic macrophages required incubation with rMuIFN-gamma in combination with 0.1 microgram of lipopolysaccharide (LPS) per ml. Splenic macrophages stimulated with rMuIFN-gamma, LPS, or rMuIFN-gamma and LPS produced tumor necrosis factor alpha (TNF-alpha), but recombinant murine TNF-alpha (rMuTNF-alpha) did not activate macrophages when used alone or as a second signal with rMuIFN-gamma. Anti-TNF-alpha antibody did not block IFN-gamma-LPS activation of splenic macrophages to any significant extent. One hundred micromolar ferrous sulfate antagonized IFN-gamma-LPS activation of splenic macrophages, indicating that iron was involved in the fungistatic activity of cytokine-stimulated phagocytes. Our results indicate that (i) splenic macrophages differ significantly from peritoneal macrophages in their requirements for activation and (ii) the mechanism by which splenic macrophages exert their antifungal effects involves iron.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.