ArticleInfection and immunity1993
Isolation and biochemical characterization of the iC3b receptor of Candida albicans.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Host-to-Pathogen Transfer of Neutrophil Components via Extracellular Vesicles Shields Candida albicans From Immune Attack in Human Blood.Journal of extracellular vesicles · 2026Article
- Activity of anti-CR3-RP polyclonal antibody against biofilms formed by Candida auris, a multidrug-resistant emerging fungal pathogen.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Supramolecular Chitosan Micro-Platelets Synergistically Enhance Anti-Candida albicans Activity of Amphotericin B Using an Immunocompetent Murine Model.Pharmaceutical research · 2017Article
- Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18.Thrombosis and haemostasis · 2015Article
- Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles.Biomaterials · 2014Article
- Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Surface glycans of Candida albicans and other pathogenic fungi: physiological roles, clinical uses, and experimental challenges.Clinical microbiology reviews · 2004Review
- The yeast Candida albicans binds complement regulators factor H and FHL-1.Infection and immunity · 2002Article
- Sialic acids in fungi: a minireview.Glycoconjugate journal · 1999Review
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Serologic response to cell wall mannoproteins and proteins of Candida albicans.Clinical microbiology reviews · 1998Review
- Expression, cloning, and characterization of a Candida albicans gene, ALA1, that confers adherence properties upon Saccharomyces cerevisiae for extracellular matrix proteins.Infection and immunity · 1997Article
- The effects of monoclonal antibodies against iC3b receptors in mice with experimentally induced disseminated candidiasis.Immunology · 1997Article
- Evidence for presence in the cell wall of Candida albicans of a protein related to the hsp70 family.Infection and immunity · 1996Article
- Production and function of cytokines in natural and acquired immunity to Candida albicans infection.Microbiological reviews · 1995Review
- Complex interaction between different proteinaceous components within the cell-wall structure of Candida albicans.Mycopathologia · 1995Article
- Evidence for the presence of collagenous domains in Candida albicans cell surface proteins.Infection and immunity · 1995Article
- Comparative study of the C3d receptor and 58-kilodalton fibrinogen-binding mannoproteins of Candida albicans.Infection and immunity · 1995Article
- Reduced inhibition of Candida albicans adhesion by saliva from patients receiving oral cancer therapy.Journal of clinical microbiology · 1995Article
- Adherence of Candida albicans to human buccal epithelial cells: host-induced protein synthesis and signaling events.Infection and immunity · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an effort to identify the protein structure on Candida albicans, pseudohyphal forms which had been shown earlier to bind human iC3b, a protein of about 42 kDa (p42), were obtained from lysates of pseudohyphal forms by absorption with C3(H2O)-Sepharose. An antiserum raised in rabbits against this protein effectively inhibited adherence of sheep erythrocytes carrying iC3b (EAC3bi) to pseudohyphal forms. p42 cross-reacted with OKM-1, a monoclonal antibody directed against the human complement receptor type 3 (CR3, CD11b). This protein, p42, was designated p42-CR3. The antiserum against p42-CR3 was used for further purification of lysates by affinity chromatography. Three proteins of 66, 55, and 42 kDa were isolated. All were recognized by OKM-1 in immunoblots (p66-, p55-, and p42-CR3). The different proteins were separated and treated with neuraminidase and endoglycosidase F. Almost complete deglycosylation of the p66-CR3 protein was obtained after treatment with neuraminidase, indicating a high degree of glycosylation. Neuraminidase also had an effect on p55-CR3, but not on p42-CR3. Endoglycosidase F did not alter any of the three proteins. In ligand blots, p42-CR3 bound C3(H2O), C3b, and iC3b but not C3d; p55-CR3 clearly reacted with C3(H2O) and weakly reacted with C3b and iC3b. p66-CR3 never showed reactivity. It is suggested that p55 and p66 represent glycosylated forms of p42-CR3. Although C. albicans CR3 and human CR3 cross-react and bind identical ligands, the two receptors differ in structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.