ReviewDrugs & aging
Free radical involvement in aging. Pathophysiology and therapeutic implications.
Review in Drugs & aging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 230 citations in OpenAlex.
- Lysergic acid diethylamide extends lifespan in Caenorhabditis elegans.Biogerontology · 2026Article
- From stress to cognitive impairment: an integrative model of oxidative and hemorheological mechanisms.Dementia & neuropsychologia · 2026Review
- Melatonin Improves Neuroprotection and Neuroplasticity in Middle-Aged Mice Following Permanent Focal Cerebral Ischemia.Molecular neurobiology · 2025Article
- Endogenous and exogenous viral reactivation as a driver of epigenetic drift and mitophagy failure in aging.Biogerontology · 2025Review
- Optimization of Exopolysaccharide Produced byFoods (Basel, Switzerland) · 2023Article
- Ginsenoside Prolongs the Lifespan ofInternational journal of molecular sciences · 2021Article
- Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects.Antioxidants (Basel, Switzerland) · 2021Review
- Aging and Protein Kinases.Advances in experimental medicine and biology · 2021Article
- An effort toward molecular biology of food deprivation induced food hoarding in gonadectomized NMRI mouse model: focus on neural oxidative status.BMC neuroscience · 2018Article
- l-Carnitine Supplementation in Recovery after Exercise.Nutrients · 2018Review
- Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation.International journal of physiology, pathophysiology and pharmacology · 2018Article
- Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats.Scientific reports · 2017Article
- A synopsis on aging-Theories, mechanisms and future prospects.Ageing research reviews · 2016Review
- Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Serum Uric Acid, Alanine Aminotransferase, Hemoglobin and Red Blood Cell Count Levels in Pseudoexfoliation Syndrome.Journal of ophthalmology · 2015Article
- The relationship between metabolic presbycusis and serum paraoxonase/arylesterase activity.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2014Article
- Antioxidants as potential therapeutics for neuropsychiatric disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2013Review
- Purification, characterization and antioxidant activities in vitro and in vivo of the polysaccharides from Boletus edulis bull.Molecules (Basel, Switzerland) · 2012Article
- Aging-induced alterations in female rat colon smooth muscle: the protective effects of hormonal therapy.Journal of physiology and biochemistry · 2012Article
- Genetic signatures of exceptional longevity in humans.PloS one · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Free radical reactions are ubiquitous in living things. Studies on the origin and evolution of life provide a reasonable explanation for the prominent presence of this unruly class of chemical reactions. These reactions have been implicated in aging. Aging is the accumulation of changes responsible for the sequential alterations that accompany advancing age, and the associated progressive increases in the chance of disease and death. Aging changes are attributed to the environment and disease, and to an inborn process, the aging process. The latter produces aging changes at an exponentially increasing rate with advancing age. Improvements in general living conditions decrease the chance of death toward limiting values. Chances for death are now near these limits in the developed countries. Future significant increases in the average life span in the developed countries can only be achieved by slowing the rate of damage produced by the aging process. Support for the possibility that free radical reactions are responsible for the aging process now includes: i) studies on the origin of life and evolution; ii) studies on the effect of ionising radiation on living things; iii) dietary manipulations of endogenous free radical reactions; iv) the plausible explanations it provides for aging phenomena; and v) the growing numbers of studies that implicate free radical reactions in the pathogenesis of specific diseases. It is reasonable to expect on the basis of present data, that the average life expectancy at birth can be increased by 5 or more years by nutritious low caloric diets supplemented with one or more free radical reaction inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.