ArticleNucleic acids research1993
Transcription factor IIA stimulates the expression of classical polIII-genes.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Tracking transcription factor complexes on DNA using total internal reflectance fluorescence protein binding microarrays.Nucleic acids research · 2009Article
- Human La is found at RNA polymerase III-transcribed genes in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Survey and summary: transcription by RNA polymerases I and III.Nucleic acids research · 2000Review
- The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter.Molecular and cellular biology · 1999Article
- Physical separation of two different forms of human TFIIIB active in the transcription of the U6 or the VAI gene in vitro.The EMBO journal · 1995Article
- Silkworm TFIIIA requires additional class III factors for commitment to transcription complex assembly on a 5S RNA gene.Nucleic acids research · 1995Article
- Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Mitotic regulation of a TATA-binding-protein-containing complex.Molecular and cellular biology · 1995Article
- Analysis of the yeast transcription factor TFIIA: distinct functional regions and a polymerase II-specific role in basal and activated transcription.Molecular and cellular biology · 1995Article
- Transcription of the human T-cell lymphotropic virus type I promoter by an alpha-amanitin-resistant polymerase.Journal of virology · 1994Article
- Silk gland-specific tRNA(Ala) genes interact more weakly than constitutive tRNA(Ala) genes with silkworm TFIIIB and polymerase III fractions.Molecular and cellular biology · 1994Article
- Transcription factors required for the expression of Xenopus laevis selenocysteine tRNA in vitro.Nucleic acids research · 1994Article
- Gene expression: surprises from the class III side.Molecular and cellular biochemistry · 1993Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein fractions containing TFIIA, a transcription factor known to be involved in transcription initiation by RNA polymerase II and 5'-regulated polymerase III genes (e.g. U6), were tested for their role in in vitro transcription of classical pol III genes. These fractions were shown to stimulate a basal transcription system, reconstituted from highly purified fractions hTFIIIB and hTFIIIC. We demonstrate that this stimulating activity isolated from HeLa cells coelutes over at least six chromatographic steps with hTFIIA. Moreover the native molecular mass and the stability of this activity against heat treatment are comparable to those of hTFIIA. Finally we show that recombinant TFIIA from Saccharomyces cerevisiae can substitute for the human factor in pol III transcription in vitro which proves that TFIIA is also involved in the efficient expression of classical pol III genes.
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