ArticleThe Journal of clinical investigation1993
Local expression of antiinflammatory cytokines in cancer.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 203 citations in OpenAlex.
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- Postoperative comparison of laparoscopic radical resection and open abdominal radical hysterectomy for cervical cancer patient.Archives of gynecology and obstetrics · 2020Article
- Effect of lentiviral vector-packaged interleukin-18 gene on the malignant behavior of lung cancer.Experimental and therapeutic medicine · 2020Article
- Endogenously Expressed IL-4Rα Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo.International journal of molecular sciences · 2017Article
- Expression of Th1- Th2- and Th17-associated cytokines in laryngeal carcinoma.Oncology letters · 2016Article
- Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- The expression levels of transcription factors T-bet, GATA-3, RORγt and FOXP3 in peripheral blood lymphocyte (PBL) of patients with liver cancer and their significance.International journal of medical sciences · 2015Article
- Modulation of Cytokines Production by Indomethacin Acute Dose during the Evolution of Ehrlich Ascites Tumor in Mice.Mediators of inflammation · 2015Article
- Type I interferons: key players in normal skin and select cutaneous malignancies.Dermatology research and practice · 2014Review
- Modulation of peripheral immune responses by paclitaxel-ifosfamide-cisplatin chemotherapy in advanced non-small-cell lung cancer.Journal of cancer research and clinical oncology · 2013Article
- Tissue-derived hedgehog proteins modulate Th differentiation and disease.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Nano size effects of TiO2 nanotube array on the glioma cells behavior.International journal of molecular sciences · 2012Article
- Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.Nature genetics · 2012Article
- Early effects of low dose C ion or x-ray irradiation on peripheral blood lymphocytes of patients with alimentary tract cancer.Dose-response : a publication of International Hormesis Society · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To characterize the nature of the local cytokine response to cancer, we chose to investigate cytokine patterns in biopsy specimens of basal cell carcinoma (BCC). We hypothesized that a distinct pattern of local cytokine production may be characteristic of BCC, a neoplasia of epidermis, in comparison to the pattern of seborrheic keratosis (SK), a benign growth of epidermis. We analyzed cytokine mRNAs in BCC versus SK by performing polymerase chain reaction on mRNA derived from biopsy specimens. The mRNAs encoding cytokines for IL-4, IL-5, IL-10, and granulocyte macrophage colony-stimulating factor were strongly expressed in BCC lesions and weakly expressed in SK lesions. Conversely, IL-2, IFN-gamma, and lymphotoxin mRNAs were strongly expressed in SK lesions and weakly expressed in BCC lesions. The response to malignancy, BCC, was typified by cytokines characteristic of murine TH2 cells. This cytokine pattern favors humoral immunity with concomitant immunosuppression of cell-mediated immune responses. In comparison, the response to the benign growth, SK, was typified by cytokines characteristic of murine TH1 cells that favor cell-mediated immune reactions. The findings of a distinct cytokine pattern in skin cancer provide a framework to develop strategies for immunologic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.