ArticleThe Journal of cell biology1993
Identification, characterization and cloning of myr 1, a mammalian myosin-I.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Oncogenic role and potential mechanisms of MYO1B in breast cancer.In vitro cellular & developmental biology. Animal · 2026Article
- Myosin Class I Genes Follow a Cell Type-Specific Transcription Pattern in Human Haematopoietic Cell Lines.International journal of molecular sciences · 2026Article
- MYO1B in human disease: an actin-based motor linking membrane trafficking to oncogenic signaling, metastasis, and vascular aging.Frontiers in oncology · 2026Review
- Review
- In pancreatic β-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi.Molecular biology of the cell · 2021Article
- Unconventional Myosins: How Regulation Meets Function.International journal of molecular sciences · 2019Review
- Myosin-I molecular motors at a glance.Journal of cell science · 2016Review
- Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells.PloS one · 2015Article
- Myosin light chains: Teaching old dogs new tricks.Bioarchitecture · 2014Review
- Regulation and control of myosin-I by the motor and light chain-binding domains.Trends in cell biology · 2013Review
- Principles of unconventional myosin function and targeting.Annual review of cell and developmental biology · 2011Review
- Localization of myosin 1b to actin protrusions requires phosphoinositide binding.The Journal of biological chemistry · 2010Article
- Control of myosin-I force sensing by alternative splicing.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Myosin I can act as a molecular force sensor.Science (New York, N.Y.) · 2008Article
- Microarray-based analysis of fish egg quality after natural or controlled ovulation.BMC genomics · 2007Article
- Temperature dependence of nucleotide association and kinetic characterization of myo1b.Biochemistry · 2006Article
- Mammalian class I myosin, Myo1b, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy.Biophysical journal · 2005Article
- A model of stereocilia adaptation based on single molecule mechanical studies of myosin I.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Article
- Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone.The Journal of cell biology · 2002Article
- Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes.Molecular biology of the cell · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified, characterized and cloned a novel mammalian myosin-I motor-molecule, called myr 1 (myosin-I from rat). Myr 1 exists in three alternative splice forms: myr 1a, myr 1b, and myr 1c. These splice forms differ in their numbers of putative calmodulin/light chain binding sites. Myr 1a-c were selectively released by ATP, bound in a nucleotide-dependent manner to F-actin and exhibited amino acid sequences characteristic of myosin-I motor domains. In addition to the motor domain, they contained a regulatory domain with up to six putative calmodulin/light chain binding sites and a tail domain. The tail domain exhibited 47% amino acid sequence identity to the brush border myosin-I tail domain, demonstrating that myr 1 is related to the only other mammalian myosin-I motor molecule that has been characterized so far. In contrast to brush border myosin-I which is expressed in mature enterocytes, myr 1 splice forms were differentially expressed in all tested tissues. Therefore, myr 1 is the first mammalian myosin-I motor molecule with a widespread tissue distribution in neonatal and adult tissues. The myr 1a splice form was preferentially expressed in neuronal tissues. Its expression was developmentally regulated during rat forebrain ontogeny and subcellular fractionation revealed an enrichment in purified growth cone particles, data consistent with a role for myr 1a in neuronal development.
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