ArticleThe Journal of cell biology1993
Relative distribution of actin, myosin I, and myosin II during the wound healing response of fibroblasts.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 145 citations in OpenAlex.
- Emergence and maintenance of variable-length actin filaments in a limiting pool of building blocks.Biophysical journal · 2022Article
- Article
- Immobilization of Antimicrobial Silver and Antioxidant Flavonoid as a Coating for Wound Dressing Materials.International journal of nanomedicine · 2019Article
- Role of Fibroblast Populations in Periodontal Wound Healing and Tissue Remodeling.Frontiers in physiology · 2019Review
- Association of hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G>A and XPD Lys751Gln polymorphisms with the survival of Malaysian NPC patients.PloS one · 2018Article
- Epidermal Stem Cells in Skin Wound Healing.Advances in wound care · 2017Review
- Pro-healing effects of bilirubin in open excision wound model in rats.International wound journal · 2016Article
- High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes.Drug design, development and therapy · 2015Article
- Cl- and K+ channels and their role in primary brain tumour biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration.American journal of physiology. Cell physiology · 2011Review
- The phosphorylation state of MRLC is polyamine dependent in intestinal epithelial cells.American journal of physiology. Cell physiology · 2011Article
- Nonmuscle myosin-dependent synthesis of type I collagen.Journal of molecular biology · 2010Article
- LPA-induced mutually exclusive subcellular localization of active RhoA and Arp2 mRNA revealed by sequential FRET and FISH.Histochemistry and cell biology · 2009Article
- Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeleton.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Retrograde flow and myosin II activity within the leading cell edge deliver F-actin to the lamella to seed the formation of graded polarity actomyosin II filament bundles in migrating fibroblasts.Molecular biology of the cell · 2008Article
- Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.The American journal of pathology · 2007Article
- Cortical actomyosin breakage triggers shape oscillations in cells and cell fragments.Biophysical journal · 2005Article
- Wound closure in the lamellipodia of single cells: mediation by actin polymerization in the absence of an actomyosin purse string.Molecular biology of the cell · 2002Article
- Two components of actin-based retrograde flow in sea urchin coelomocytes.Molecular biology of the cell · 1999Article
- Leukocyte polarization in cell migration and immune interactions.The EMBO journal · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myosin I is present in Swiss 3T3 fibroblasts and its localization reflects a possible involvement in the extension and/or retraction of protrusions at the leading edge of locomoting cells and the transport of vesicles, but not in the contraction of stress fibers or transverse fibers. An affinity-purified polyclonal antibody to brush border myosin I colocalizes with a polypeptide of 120 kD in fibroblast extracts. Within initial protrusions of polarized, migrating fibroblasts, myosin I exhibits a punctate distribution, whereas actin is diffuse and myosin II is absent. Myosin I also exists in linear arrays parallel to the direction of migration in filopodia and microspikes, established protrusions, and within the leading lamellae of migrating cells. Myosin II and actin colocalize along transverse fibers in the lamellae of migrating cells, while myosin I displays no definitive organization along these fibers. During contractions of actin-based fibers, myosin II is concentrated in the center of the cell, while the distribution of myosin I does not change. Thus, myosin I is found at the correct location and time to be involved in the extension and/or retraction of protrusions and the transport of vesicles. Myosin II-based contractions in more posterior cellular regions could generate forces to separate cells, maintain a polarized cell shape, maintain the direction of locomotion, maximize the rate of locomotion, and/or aid in the delivery of cytoskeletal/contractile subunits to the leading edge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.