ArticleNaunyn-Schmiedeberg's archives of pharmacology1993
[3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 72 citations in OpenAlex.
- TRPV1 channel in spermatozoa is a molecular target for ROS-mediated sperm dysfunction and differentially expressed in both natural and ART pregnancy failure.Frontiers in cell and developmental biology · 2022Article
- TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in OProceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- TRP Channels as Therapeutic Targets in Diabetes and Obesity.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification.The Journal of biological chemistry · 2016Article
- Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity.The Journal of biological chemistry · 2014Article
- The TRPA1 channel in migraine mechanism and treatment.British journal of pharmacology · 2014Review
- Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates.The Journal of biological chemistry · 2012Article
- Cold suppresses agonist-induced activation of TRPV1.Journal of dental research · 2011Article
- The biophysical and molecular basis of TRPV1 proton gating.The EMBO journal · 2011Article
- Novel insights on diagnosis, cause and treatment of diabetic neuropathy: focus on painful diabetic neuropathy.Therapeutic advances in endocrinology and metabolism · 2010Article
- A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors.British journal of pharmacology · 1999Article
- Differential activation and desensitization of sensory neurons by resiniferatoxin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety.British journal of pharmacology · 1996Article
- Capsaicin-induced relaxation in the rat isolated external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP.British journal of pharmacology · 1993Article
- Vanilloid receptors in the urinary bladder: regional distribution, localization on sensory nerves, and species-related differences.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specific binding of [3H]resiniferatoxin (RTX) is thought to represent the vanilloid (capsaicin) receptor. In the present study, we have used this binding assay to elucidate the contribution of differential receptor expression to the capsaicin-resistance of hamsters and rabbits; binding parameters were compared to those of species (rats, mice) regarded as capsaicin-sensitive. Whereas the 5-fold lower affinity for [3H]RTX binding in the hamster (100 pM) as compared to the rat (20 pM) is unlikely to account for the 100-fold difference in the in vivo responses of RTX-induced inflammation and hypothermia, the lack of detectable specific [3H]RTX binding sites in the rabbit might represent the predominant mechanism of capsaicin-resistance in this species. Regulation of the vanilloid receptor was further characterized in the rat. In accord with the temperature dependence of both in vivo and in vitro capsaicin actions, we found a marked temperature dependence for association rates. Dissociation turned out to have complex kinetics dependent on time and receptor occupancy. Low pH (5.5-7.0) did not affect receptor binding. Preincubation with heavy metal cations and other sulfhydryl-reactive agents inhibited specific [3H]RTX binding indicating that the vanilloid receptor is a thiol-protein, and that free sulfhydryl groups play an essential role in agonist binding activity. Preliminary characterization suggested noncompetitive inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.