ArticleJournal of virology1993
A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 91 citations in OpenAlex.
- The prohibitin-repressive interaction with E2F1 is rapidly inhibited by androgen signalling in prostate cancer cells.Oncogenesis · 2017Article
- Article
- Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid.Oncogene · 2006Review
- EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.Molecular biology of the cell · 2005Article
- Activation of CREB/ATF sites by polyomavirus large T antigen.Journal of virology · 2005Article
- Transactivation of E2F-regulated genes by polyomavirus large T antigen: evidence for a two-step mechanism.Molecular and cellular biology · 2004Article
- Polyomavirus tumorantigens have a profound effect on gene expression in mouse fibroblasts.Oncogene · 2004Article
- Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents.Oncogene · 2004Article
- Article
- Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.Molecular and cellular biology · 2002Article
- Transactivation of murine cyclin A by polyomavirus large and small T antigens.Journal of virology · 2001Article
- Proliferating cell nuclear antigen transcription is repressed through an E2F consensus element and activated by geminivirus infection in mature leaves.The Plant cell · 2001Article
- Target gene specificity of E2F and pocket protein family members in living cells.Molecular and cellular biology · 2000Article
- J domain-independent regulation of the Rb family by polyomavirus large T antigen.Journal of virology · 2000Article
- Binding of polyomavirus small T antigen to protein phosphatase 2A is required for elimination of p27 and support of S-phase induction in concert with large T antigen.Journal of virology · 1999Article
- Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication.Molecular and cellular biochemistry · 1999Article
- Polyomavirus large T antigen binds the transcriptional coactivator protein p300.Journal of virology · 1999Article
- PCF1 and PCF2 specifically bind to cis elements in the rice proliferating cell nuclear antigen gene.The Plant cell · 1997Article
- E2F-dependent mitogenic stimulation of the splicing of transcripts from an S phase-regulated gene.Nucleic acids research · 1997Article
- Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The promoter of the murine thymidine kinase gene contains a binding site for transcription factor E2F. Using cell lines (3T3-LT) conditionally expressing polyomavirus large T antigen from a hormone-responsive promoter and reporter gene constructs carrying the thymidine kinase promoter with intact or mutated E2F sites, we show that this E2F site is the target for trans activation by the viral protein. Transcription of the growth-regulated endogenous thymidine kinase gene can be activated in serum-starved, quiescent 3T3-LT cells by induction of T antigen. Activation of transcription from the thymidine kinase promoter requires an intact binding site for the retinoblastoma protein in the T antigen. The same promoter region was furthermore shown to play a major role in growth regulation of the gene. As several other DNA synthesis enzymes also carry E2F binding sites in their promoters, our observations suggest a common mechanism of growth regulation of these genes and that they all might be targets for trans activation by DNA tumor virus proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.