ArticleMolecular biology of the cell1993
NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.
Article in Molecular biology of the cell, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 118 citations in OpenAlex.
- Dissecting the roles of Cse1 and Nup2 in classical NLS-cargo release in vivo.Traffic (Copenhagen, Denmark) · 2020Article
- The yeast Ty1 retrotransposon requires components of the nuclear pore complex for transcription and genomic integration.Nucleic acids research · 2018Article
- The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis.Genetics · 2017Article
- Sumoylation and transcription regulation at nuclear pores.Chromosoma · 2015Review
- Individual binding pockets of importin-beta for FG-nucleoporins have different binding properties and different sensitivities to RanGTP.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Single-molecule measurements of importin alpha/cargo complex dissociation at the nuclear pore.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.Molecular biology of the cell · 2006Article
- Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p.Genetics · 2005Article
- Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import.The EMBO journal · 2003Article
- The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex.The Journal of cell biology · 2001Article
- An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport.The EMBO journal · 2001Article
- Nup2p dynamically associates with the distal regions of the yeast nuclear pore complex.The Journal of cell biology · 2001Article
- Article
- Factors affecting nuclear export of the 60S ribosomal subunit in vivo.Molecular biology of the cell · 2000Article
- Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.Molecular and cellular biology · 2000Article
- Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway.Molecular and cellular biology · 2000Article
- Nuclear export of the small ribosomal subunit requires the ran-GTPase cycle and certain nucleoporins.Genes & development · 1999Article
- Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.Molecular and cellular biology · 1998Article
- The nuclear pore complex.Plant molecular biology · 1998Review
- A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have isolated a new gene, NUP2, that encodes a constituent of the yeast-nuclear pore complex (NPC). The NUP2 protein sequence shares a central repetitive domain with NSP1 and NUP1, the two previously characterized yeast nucleoporins. Like NUP1 and NSP1, NUP2 localizes to discrete spots in the nuclear envelope, as determined by indirect immunofluorescence. Although the sequence similarity among these three nucleoporins suggests that they have a similar role in the nuclear pore complex, NUP2, in contrast to NSP1 and NUP1, is not required for growth. Some combinations of mutant alleles of NUP1, NSP1, and NUP2 display "synthetic lethal" relationships that provide evidence for functional interaction between these NPC components. This genetic evidence of overlapping function suggests that the nucleoporins act in concert, perhaps participating in the same step of the recognition or transit of macromolecules through the NPC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.