ArticleMolecular biology of the cell1993
Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1.
Article in Molecular biology of the cell, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 74 citations in OpenAlex.
- Comparative analysis of commercial human primary mesangial cell, implications for experimental design.BMC nephrology · 2025Article
- The Configuration of GRB2 in Protein Interaction and Signal Transduction.Biomolecules · 2024Review
- NF-kappaB controls growth of glioblastomas/astrocytomas.Molecular and cellular biochemistry · 2008Article
- Two conserved cysteine residues are critical for the enzymic function of the human platelet-derived growth factor receptor-beta: evidence for different roles of Cys-822 and Cys-940 in the kinase activity.The Biochemical journal · 2004Article
- BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.The EMBO journal · 2002Article
- Article
- Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.Molecular biology of the cell · 2001Article
- Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways.Genes & development · 2000Article
- Physiological requirement for both SH2 domains for phospholipase C-gamma1 function and interaction with platelet-derived growth factor receptors.Molecular and cellular biology · 1999Article
- STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation.Oncogene · 1999Article
- Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.Molecular and cellular biology · 1998Article
- Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation.Molecular and cellular biology · 1997Article
- The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor.Molecular and cellular biology · 1995Article
- Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.The Journal of cell biology · 1995Article
- Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation.Molecular and cellular biology · 1995Article
- Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling.Molecular and cellular biology · 1995Article
- Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.The Biochemical journal · 1995Article
- Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.Molecular and cellular biology · 1994Article
- Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have identified two tyrosine phosphorylation sites, Tyr 1009 and Tyr 1021, in the C-terminal noncatalytic region of the human platelet-derived growth factor (PDGF) receptor beta subunit. Mutant receptors with phenylalanine substitutions at either or both of these tyrosines were expressed in dog epithelial cells. Mutation of Tyr 1021 markedly reduced the PDGF-stimulated binding of phospholipase C (PLC) gamma 1 but had no effect on binding of the GTPase activator protein of Ras or of phosphatidylinositol 3 kinase. Mutation of Tyr 1009 reduced binding of PLC gamma 1 less severely. Mutation of Tyr 1021, or both Tyr 1009 and Tyr 1021, also reduced the PDGF-dependent binding of a transiently expressed fusion protein containing the two Src-homology 2 domains from PLC gamma 1. Mutation of Tyr 1021, or both Tyr 1009 and Tyr 1021, greatly reduced PDGF-stimulated tyrosine phosphorylation of PLC gamma 1 but did not prevent the tyrosine phosphorylation of other cell proteins, including mitogen-activated protein kinase. We conclude that Tyr 1021, and possibly Tyr 1009, is a binding site for PLC gamma 1.
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