ArticleMolecular and cellular biology1993
Alpha B-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 125 citations in OpenAlex.
- Trait Loss in Evolution: What Cavefish Have Taught Us about Mechanisms Underlying Eye Regression.Integrative and comparative biology · 2023Review
- Article
- Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart.The Journal of biological chemistry · 2018Article
- Molecular mechanism of formation of cortical opacity in CRYAAN101D transgenic mice.Investigative ophthalmology & visual science · 2014Article
- Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts.The Journal of biological chemistry · 2013Article
- Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update.Archives of toxicology · 2013Review
- αB-crystallin/sHSP protects cytochrome c and mitochondrial function against oxidative stress in lens and retinal cells.Biochimica et biophysica acta · 2012Article
- Impact of diabetes on alpha-crystallins and other heat shock proteins in the eye.Journal of ocular biology, diseases, and informatics · 2011Article
- αB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells.The American journal of pathology · 2010Article
- Dose- and time-dependent glucocorticoid receptor signaling in podocytes.American journal of physiology. Renal physiology · 2010Article
- The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity.Cell death & disease · 2010Article
- Mechanism of cataract formation in alphaA-crystallin Y118D mutation.Investigative ophthalmology & visual science · 2009Article
- Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Thermally induced and developmentally regulated expression of a small heat shock protein in Trichinella spiralis.Parasitology research · 2007Article
- Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress.Experimental cell research · 2007Article
- Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone.The protein journal · 2006Article
- Expression and regulation of alphaB-crystallin in the kidney in vivo and in vitro.Pflugers Archiv : European journal of physiology · 2006Article
- Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock.Molecular biology of the cell · 2006Article
- Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology.The American journal of pathology · 2004Article
- Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
alpha B-crystallin, a major soluble protein of vertebrate eye lenses, is a small heat shock protein which transiently accumulates in response to heat shock and other kinds of stress in mouse NIH 3T3 fibroblasts. Ectopic expression of an alpha B-crystallin cDNA clone renders NIH 3T3 cells thermoresistant. alpha B-crystallin accumulates in response to the synthetic glucocorticoid hormone dexamethasone. Dexamethasone-treated NIH 3T3 cells become thermoresistant to the same extent as they accumulate alpha B-crystallin. A cell clone in which alpha B-crystallin is superinduced upon heat shock acquires augmented thermotolerance. Expression of the ras oncogene causes a rapid but transient accumulation of alpha B-crystallin within 1 day. Later, sustained ras oncogene expression suppresses the dexamethasone-mediated alpha B-crystallin accumulation. Thus, oncogenic transformation triggered by the ras oncogene interferes with hormone-mediated accumulation of alpha B-crystallin and concomitant acquisition of thermoresistance. Other known heat shock proteins do not accumulate in response to ectopic alpha B-crystallin expression or to dexamethasone treatment. These results indicate that alpha B-crystallin can protect NIH 3T3 fibroblasts from thermal shock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.