ArticleMolecular and cellular biology1993
Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 136 citations in OpenAlex.
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells.Cell death & disease · 2019Article
- How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?Cell death and differentiation · 2018Review
- Review
- Article
- p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.Genes & cancer · 2011Article
- Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation.Retrovirology · 2008Review
- Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-alpha.The Journal of biological chemistry · 2008Article
- Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis.The Journal of biological chemistry · 2008Article
- Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1.Oncogene · 2008Article
- p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest.Molecular and cellular biology · 2005Article
- Article
- Article
- Normal p53 function in primary cells deficient for Siah genes.Molecular and cellular biology · 2002Article
- Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1.Journal of virology · 2002Article
- Article
- Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts.Oncogene · 2001Article
- Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia.Oncogene · 2001Article
- Bcl-2 expression in F-MuLV-induced erythroleukemias: a role for the anti-apoptotic action of Bcl-2 during tumor progression.Oncogene · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The murine allele temperature-sensitive (ts) p53Val-135 encodes a ts p53 protein that behaves as a mutant polypeptide at 37 degrees C and as a wild-type polypeptide at 32 degrees C. This ts allele was introduced into the p53 nonproducer Friend erythroleukemia cell line DP16-1. The DP16-1 cell line was derived from the spleen cells of a mouse infected with the polycythemia strain of Friend virus, and like other erythroleukemia cell lines transformed by this virus, it grows independently of erythropoietin, likely because of expression of the viral gp55 protein which binds to and activates the erythropoietin receptor. When incubated at 32 degrees C, DP16-1 cells expressing ts p53Val-135 protein, arrested in the G0/G1 phase of the cell cycle, rapidly lost viability and expressed hemoglobin, a marker of erythroid differentiation. Erythropoietin had a striking effect on p53Val-135-expressing cells at 32 degrees C by prolonging their survival and diminishing the extent of hemoglobin production. This response to erythropoietin was not accompanied by down-regulation of viral gp55 protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.