ArticleJournal of cancer research and clinical oncology1993
Molecular mechanism of stomach carcinogenesis.
Article in Journal of cancer research and clinical oncology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 328 citations in OpenAlex.
- Association of APC gene promoter methylation and the risk of gastric cancer: A meta-analysis and bioinformatics study.Medicine · 2020Pooled it
- Therapeutic strategy for scirrhous type gastric cancer.Japanese journal of clinical oncology · 2025Review
- Update on molecular pathogenesis ofWorld journal of gastrointestinal pathophysiology · 2025Review
- Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Downregulates GCNT3 via the TGF-β1/Smad-mTORC1 Signaling Axis.Journal of virology · 2021Article
- Anticancer Effects ofJournal of Cancer · 2021Article
- Role of HGF/c-Met in the treatment of colorectal cancer with liver metastasis.Journal of biochemical and molecular toxicology · 2019Article
- Protein kinase Cι is a new prognostic factor in gastric cancer.Surgery today · 2015Article
- Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer.The Journal of pathology · 2014Article
- Potential prognostic, diagnostic and therapeutic markers for human gastric cancer.World journal of gastroenterology · 2014Review
- Clinicopathological significance of NMIIA overexpression in human gastric cancer.International journal of molecular sciences · 2012Article
- Gastric carcinogenesis.World journal of gastroenterology · 2012Article
- Endocrine carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single institute.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2012Article
- Telomere shortening occurs early during gastrocarcinogenesis.Medical oncology (Northwood, London, England) · 2012Article
- Overexpression of ADP-ribosylation factor 1 in human gastric carcinoma and its clinicopathological significance.Cancer science · 2012Article
- The combined expression of metaplasia biomarkers predicts the prognosis of gastric cancer.Annals of surgical oncology · 2012Article
- Association between Genetic Instability and Helicobacter pylori Infection in Gastric Epithelial Dysplasia.Gastroenterology research and practice · 2012Article
- p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2011Article
- Interleukin-10 -1082 promoter polymorphism and gastric cancer risk in a Chinese Han population.Molecular and cellular biochemistry · 2011Article
- Microsatellite instability is associated with the clinicopathologic features of gastric cancer in sporadic gastric cancer patients.Journal of gastric cancer · 2010Article
- Mucin phenotype of gastric cancer and clinicopathology of gastric-type differentiated adenocarcinoma.World journal of gastroenterology · 2010Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene changes in multiple oncogenes, multiple growth factors and multiple tumor-suppressor genes are observed in stomach cancer. Among them, those most commonly implicated in both well-differentiated adenocarcinoma and poorly differentiated adenocarcinoma are inactivation (mutations and allele loss) of the p53 gene, and activation (abnormal expression and amplification) of the c-met gene. Moreover, they occur at an early stage of stomach carcinogenesis. In addition, loss of heterozygosity (LOH) on chromosome 5q (APC locus) is frequently associated with well-differentiated adenocarcinoma. LOH on chromosome 18q (DCC locus) and LOH of the bcl-2 gene also are common events of well-differentiated adenocarcinoma. LOH on chromosomes 1q and 7q may be involved in the progression of well-differentiated adenocarcinoma. Conversely, the development of poorly differentiated adenocarcinoma, in addition to changes in p53 and c-met genes, requires reduction or dysfunction of cadherin. Overexpression of bcl-2 protein is observed in poorly differentiated adenocarcinoma or signet-ring cell carcinoma. Moreover, the K-sam gene is amplified preferentially in poorly differentiated adenocarcinoma of scirrhous carcinoma. K-sam amplification in scirrhous carcinoma often occurs independently of c-met gene amplification. LOH on chromosome 1p also is relatively common in poorly differentiated adenocarcinoma. Exceptionally, signet-ring cell carcinoma shares APC mutations. There are some differences in expression of the growth-factor/receptor system between well-differentiated adenocarcinoma and poorly differentiated adenocarcinoma. Moreover, interaction between cell-adhesion molecules in tumor cells expressing c-met and hepatocyte growth factor (HGF) from stromal cells is linked with morphogenesis of two histological types of stomach cancer. Intestinal metaplasia and adenoma of the stomach also contain p53 mutations and K-ras mutations or tpr-met rearrangement. Taken together, different genetic pathways of stomach carcinogenesis may exist for poorly differentiated and well-differentiated stomach cancers. Some of the latter may develop by a cumulative series of gene alterations similar to those of colorectal cancer.
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