ArticleThe EMBO journal1993
Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 131 citations in OpenAlex.
- Peripherally induced human regulatory T cells uncouple Kv1.3 activation from TCR-associated signaling.European journal of immunology · 2011Article
- Integrating signals from the T-cell receptor and the interleukin-2 receptor.PLoS computational biology · 2011Article
- Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.Journal of virology · 2011Article
- T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis.Immunity · 2010Article
- Article
- Maternal microchimerism leads to the presence of interleukin-2 in interleukin-2 knock out mice: implications for the role of interleukin-2 in thymic function.Cellular immunology · 2007Article
- HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.Journal of biosciences · 2003Review
- Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases.Molecular and cellular biology · 2001Article
- Signal-transduction defects in T cells.Clinical reviews in allergy & immunology · 2001Review
- Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.Molecular and cellular biology · 2000Article
- Review
- Interleukin 2-mediated uncoupling of T cell receptor alpha/beta from CD3 signaling.The Journal of experimental medicine · 1998Article
- Recent advances in the understanding of interleukin-2 signal transduction.Journal of clinical immunology · 1998Review
- Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity.Journal of virology · 1996Article
- Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Evolution of the src-related protein tyrosine kinases.Journal of molecular evolution · 1996Article
- Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Involvement of p59fynT in interleukin-5 receptor signaling.The Journal of experimental medicine · 1995Article
- Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies demonstrate that p56lck, a member of the src-family of protein tyrosine kinases (PTKs), can physically associate with the interleukin-2 (IL-2) receptor beta chain (IL-2R beta) and that IL-2 receptor engagement stimulates p56lck activity. To examine the mechanisms underlying p56lck PTK activation by IL-2, we established a mouse pro-B cell line, BAF-B03, expressing both IL-2R beta (either the wild-type or mutant forms) and mouse p56lck at high levels. BAF-B03 cells expressing a mutant IL-2R beta chain lacking an 'acidic' region of the cytoplasmic domain, previously shown to be essential for association with p56lck, fail to induce p56lck PTK activation upon IL-2 stimulation. This suggests that the association of p56lck with the IL-2R beta chain, despite its low stoichiometry, is required for the activation of cellular p56lck PTK upon IL-2 stimulation. Intriguingly, BAF-B03 cells expressing an IL-2R beta chain which lacks a different cytoplasmic region, the 'serine-rich' region, also fail to activate p56lck in response to IL-2. Hence, physical association of p56lck with the IL-2R beta chain is not by itself sufficient to permit IL-2-mediated regulation of this PTK. Additional experiments suggest that one result of PTK activation is the accumulation of c-fos and c-jun transcripts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.