ArticleThe EMBO journal1993
Divergent evolution of T cell repertoires: extensive diversity and developmentally regulated expression of the sheep gamma delta T cell receptor.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Review
- The Camel Adaptive Immune Receptors Repertoire as a Singular Example of Structural and Functional Genomics.Frontiers in genetics · 2019Review
- Sheep (Ovis aries) T cell receptor alpha (TRA) and delta (TRD) genes and genomic organization of the TRA/TRD locus.BMC genomics · 2015Article
- Coevolution of T-cell receptors with MHC and non-MHC ligands.Immunological reviews · 2015Review
- Ovine skin-recirculating γδ T cells express IFN-γ and IL-17 and exit tissue independently of CCR7.Veterinary immunology and immunopathology · 2013Article
- Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: a unique landscape of innate immunity.Immunology letters · 2013Review
- Annotation and classification of the bovine T cell receptor delta genes.BMC genomics · 2010Article
- The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2.Immunogenetics · 2009Article
- Genomic organization and recombinational unit duplication-driven evolution of ovine and bovine T cell receptor gamma loci.BMC genomics · 2008Article
- Molecular in situ hybridization analysis of sheep and goat BAC clones identifies the transcriptional orientation of T cell receptor gamma genes on chromosome 4 in bovids.Veterinary research communications · 2007Article
- Identification of three new bovine T-cell receptor delta variable gene subgroups expressed by peripheral blood T cells.Immunogenetics · 2006Article
- Differential TCR gene usage between WC1- and WC1+ ruminant gammadelta T cell subpopulations including those responding to bacterial antigen.Immunogenetics · 2006Article
- Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells.Immunogenetics · 2006Article
- Characterization of the T-cell receptor gamma locus and analysis of the variable gene segment expression in rabbit.Immunogenetics · 2005Article
- Artiodactyl emergence is accompanied by the birth of an extensive pool of diverse germline TRDV1 genes.Immunogenetics · 2005Article
- Genomic structure around joining segments and constant regions of swine T-cell receptor alpha/delta (TRA/TRD) locus.Immunology · 2003Article
- Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus.Journal of molecular evolution · 2003Article
- gammadelta(+) T-Lp6phocyte cytotoxicity against envelope-expressing target cells is unique to the alymphocytic state of bovine leukemia virus infection in the natural host.Journal of virology · 2000Article
- Bovine gammadelta T-cell responses to the intracellular protozoan parasite Theileria parva.Infection and immunity · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sheep gamma delta T cells express an unprecedented repertoire of antigen receptors contributed by increased diversity in both variable and constant region gene segments. Variable region diversity results mainly from the utilization of a large family of duplicated V delta genes that have retained two distinct hypervariable segments comparable with the complementarity determining regions present in other antigen receptor V genes. This implies that sheep V delta chains have been intensely selected during evolution, probably at sites involved in ligand recognition. The sheep gamma delta heterodimer occurs in at least five isotypic variants formed by the association of a single C delta segment with one of five functional C gamma segments, each with distinctive hinge regions. Our analysis also shows that the establishment of a normal peripheral repertoire is both developmentally regulated and dependent on the continual presence of a functional thymus during ontogeny. The existence of an expanded V gene repertoire and multiple receptor isotypes together with the prominence of gamma delta T cells in the sheep immune system argues that this lineage of T cells has a more elaborate functional role in this evolutionary pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.