ArticleBreast cancer research and treatment1993
Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays.
Article in Breast cancer research and treatment, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 120 citations in OpenAlex.
- Progression after First-Line Cyclin-Dependent Kinase 4/6 Inhibitor Treatment: Analysis of Molecular Mechanisms and Clinical Data.International journal of molecular sciences · 2023Review
- 3D Modeling of Epithelial Tumors-The Synergy between Materials Engineering, 3D Bioprinting, High-Content Imaging, and Nanotechnology.International journal of molecular sciences · 2021Review
- Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer.Clinical proteomics · 2020Article
- Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1.Journal of breast cancer · 2019Article
- Three-dimensional cage-like microscaffolds for cell invasion studies.Scientific reports · 2015Article
- Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.PloS one · 2015Article
- Wnt/β-catenin pathway is required for epithelial to mesenchymal transition in CXCL12 over expressed breast cancer cells.International journal of clinical and experimental pathology · 2015Article
- Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells.Oncogene · 2014Article
- Article
- Luminal breast cancer metastasis is dependent on estrogen signaling.Clinical & experimental metastasis · 2012Article
- The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).The Journal of biological chemistry · 2012Article
- LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer.Cancer research · 2010Article
- Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.PloS one · 2009Article
- The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha.Molecular endocrinology (Baltimore, Md.) · 2007Article
- TGF-beta and BMP7 interactions in tumour progression and bone metastasis.Clinical & experimental metastasis · 2007Review
- Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase.Molecular cancer · 2006Article
- LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines.Clinical & experimental metastasis · 2004Article
- The potential role of bisphosphonates in prostate cancer.Prostate cancer and prostatic diseases · 2002Review
- Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures.British journal of cancer · 2001Article
- Effects of hyaluronan on the invasive properties of human breast cancer cells in vitro.International journal of experimental pathology · 2001Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
In vitro analyses of basement membrane invasiveness employing Matrigel (a murine tumor extract rich in basement membrane components) have been performed on human breast cancer model systems. Constitutive invasiveness of different human breast cancer (HBC) cell lines has been examined as well as regulation by steroid hormones, growth factors, and oncogenes. Carcinoma cells exhibiting a mesenchymal-like phenotype (vimentin expression, lack of cell border associated uvomorulin) show dramatically increased motility, invasiveness, and metastatic potential in nude mice. These findings support the hypothesis that epithelial to mesenchymal transition (EMT)-like events may be instrumental in the metastatic progression of human breast cancer. The MCF-7 subline MCF-7ADR appears to have undergone such a transition. The importance of such a transition may be reflected in the emergence of vimentin expression as an indicator of poor prognosis in HBC. Matrix degradation and laminin recognition are highlighted as potential targets for antimetastatic therapy, and analyses of laminin attachment and the matrix metalloproteinase (MMP) family in HBC cell lines are summarized. Matrigel-based assays have proved useful in the study of the molecular mechanisms of basement membrane invasiveness, their regulation in HBC cells, and their potential as targets for antimetastatic therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.