ArticleThe Biochemical journal1993
Cloning and characterization of the rat bone sialoprotein gene promoter.
Article in The Biochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 99 citations in OpenAlex.
- Review
- Vitamin K and D Supplementation and Bone Health in Chronic Kidney Disease-Apart or Together?Nutrients · 2021Review
- Article
- Effects of interleukin-11 on the expression of human bone sialoprotein gene.Journal of bone and mineral metabolism · 2015Article
- Vitamin D and gene networks in human osteoblasts.Frontiers in physiology · 2014Review
- Applications of transgenics in studies of bone sialoprotein.Journal of cellular physiology · 2009Review
- Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Birth defects research. Part B, Developmental and reproductive toxicology · 2007Review
- Identification of a vitamin D3-response element that overlaps a unique inverted TATA box in the rat bone sialoprotein gene.The Biochemical journal · 1996Article
- An inverted TATA box directs downstream transcription of the bone sialoprotein gene.The Biochemical journal · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the transcriptional regulation of the rat bone sialoprotein (BSP) gene, the nucleotide sequence of a approximately 1 kb HindIII/KpnI subfragment from a genomic clone containing the 5' flanking sequence, exon 1 and part of intron 1 was determined and the transcription start site defined. This region includes an inverted TATA element (nt -24 to -19), an inverted CCAAT box, a homeobox-binding site, a putative 1,25-dihydroxyvitamin D3 response element (VDRE) sequence overlapping the inverted TATA sequence, and a novel 18 nt palindrome that may control the tissue-specific transcription of the BSP gene. The shortest promoter sequence capable of directing bacterial chloramphenicol acetyltransferase reporter gene expression included the inverted TATA element and the inverted CCAAT box. However, the promoter activity was down-regulated by 1,25-dihydroxyvitamin D3, indicating that the unique VDRE-like sequence overlapping the TATA element is functional. Thus the rat BSP gene promoter is characterized by novel cis-acting elements that may be involved in hormone- and tissue-specific regulation of transcription.
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Registered trials
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