ArticleThe American journal of pathology1993
Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 100 citations in OpenAlex.
- Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series.World journal of gastroenterology · 2017Article
- Expression profile of E-cadherin, estrogen receptors, and P53 in early-onset gastric cancers.Cancer medicine · 2016Article
- Immunohistochemistry of whole-organ sections of advanced human laryngeal cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2006Article
- Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma.The American journal of pathology · 2000Article
- A human natural antibody to adenocarcinoma that inhibits tumour cell migration.British journal of cancer · 1998Article
- Immunohistochemical video-microdensitometry of myocardial collagen type I and type III.The Histochemical journal · 1998Article
- p53 protein overexpression as a predictor of the response to chemotherapy in gastric cancer.Surgery today · 1998Article
- Prognostic significance of Ki-67 antigen and p53 protein expression in pancreatic duct carcinoma: a study of the monoclonal antibodies MIB-1 and DO-7 in formalin-fixed paraffin-embedded tumour material.British journal of cancer · 1997Article
- Keratin antigen retrieval in oral mucosal biopsies using microwave processing.The Histochemical journal · 1996Article
- Relationship between CD44 expression and cell proliferation in epithelium and stroma of colorectal neoplasms.The American journal of pathology · 1996Article
- p16/CDKN2 gene and p53 gene alterations in Japanese non-smoking female lung adenocarcinoma.Japanese journal of cancer research : Gann · 1996Article
- Midgut Carcinoids and Solid Carcinomas of the Intestine: Differences in Endocrine Markers and p53 Mutations.Endocrine pathology · 1996Article
- Quantitative in situ image analysis of apoptosis in well and poorly differentiated tumors from rat liver.The American journal of pathology · 1995Article
- DNA aberrations in the epithelial cell component of adamantinoma of long bones.The American journal of pathology · 1995Article
- Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.Journal of neurology, neurosurgery, and psychiatry · 1995Article
- Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma.British journal of cancer · 1995Article
- Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma.The American journal of pathology · 1995Article
- Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.Journal of clinical pathology · 1995Article
- Article
- Effects of antigen retrieval by microwave heating in formalin-fixed tissue sections on a broad panel of antibodies.Histochemistry · 1994Article
Corrections and comments
- Commented on byWhat is TUF?1994
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the aid of a newly developed target unmasking fluid (TUF), p53 overexpression was visualized by immunohistochemistry on recent and archival paraffin-embedded tissue samples of colon, stomach, and pancreas neoplasms. Using monoclonal anti-p53 antibody pAb1801 as well as polyclonal antiserum to p53 CM1, TUF-mediated immunohistochemistry was fully concordant for p53 overexpression in paraffin-embedded carcinoma samples compared with freshly frozen tissue from the same tumors. Thus, prognostic and diagnostic assessment of p53 overexpression in malignant tissue, routinely fixed in formalin and embedded in paraffin wax, by TUF-mediated immunohistochemistry with monoclonal and polyclonal antibodies may be adopted as a new tool in diagnostic and research histopathology.
Indexed as
Identifiers
8434637PMC1886719W177842337What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.