ArticleThorax1993
Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness.
Article in Thorax, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 187 citations in OpenAlex.
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- Allergen-Specific CD4(+) T Cells in Human Asthma.Annals of the American Thoracic Society · 2016Review
- Orally administered β-glucan attenuates the Th2 response in a model of airway hypersensitivity.SpringerPlus · 2016Article
- Interleukin-10 and interleukin-5 balance in patients with active asthma, those in remission, and healthy controls.Asia Pacific allergy · 2015Article
- Thymic stromal lymphopoietin signaling in CD4(+) T cells is required for TH2 memory.The Journal of allergy and clinical immunology · 2015Article
- Effector and central memory T helper 2 cells respond differently to peptide immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4+ T lymphocytes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- Unusual asthma syndromes and their management.Therapeutic advances in chronic disease · 2011Article
- Functional invariant NKT cells in pig lungs regulate the airway hyperreactivity: a potential animal model.Journal of clinical immunology · 2011Article
- Article
- Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure.American journal of respiratory cell and molecular biology · 2011Article
- Recommendation for optimal management of severe refractory asthma.Journal of asthma and allergy · 2010Article
- Surface markers of lymphocyte activation in pregnant asthmatics.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchial mucosal inflammation and epithelial damage are characteristic features of asthma. Activation of T helper lymphocytes may contribute to this process by mechanisms including the release of cytokines promoting eosinophil infiltration and activation.
methodsBronchial washings and bronchoalveolar lavage fluid were obtained from 29 atopic asthmatic patients (19 with current symptoms and 10 symptom free) and 13 normal volunteers. Flow cytometry was used to assess T cell phenotype and activation status in bronchoalveolar lavage fluid and peripheral blood, and differential cell counts were made on bronchial washings and bronchoalveolar lavage fluid. Findings were related to severity of disease as reflected by symptom scores, baseline lung function, and airway responsiveness.
resultsCD4 T lymphocytes in bronchoalveolar lavage fluid and blood from asthmatic patients were activated by comparison with controls (CD4 CD25, median 16.8% v 8.7% for bronchoalveolar lavage fluid, and 15.3% v 8.7% in blood). Bronchoalveolar lavage fluid CD4 T cells from both asthmatic patients and controls were of memory phenotype (95.8% and 96.8% CD45RO and 1.7% and 0.4% CD45RA respectively), whereas both CD45RO and CD45RA T cells were present in blood. Patients with asthma and current symptoms showed increased bronchoalveolar T cell activation compared with patients without symptoms (CD4 CD25 18.7% v 12.3%). Within the asthmatic group there was a significant association between CD4 CD25 lymphocytes and asthma symptom scores (rs = 0.75), airway methacholine responsiveness (log PC20, rs = -0.43) and baseline FEV1 (rs = -0.39). A correlation was also found between CD4 CD25 lymphocytes and eosinophils in bronchoalveolar lavage fluid (rs = 0.48). Eosinophils in bronchoalveolar lavage fluid were increased in asthmatic patients compared with controls and the percentage of eosinophils in bronchoalveolar lavage fluid correlated with asthma symptom score. A relation was found between percentage of epithelial cells in bronchoalveolar lavage fluid and FEV1 and methacholine PC20.
conclusionThese results support the hypothesis that selective activation of memory CD4 T cells contributes to eosinophil accumulation, bronchial hyperresponsiveness, and symptoms in asthma.
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