ArticleProceedings of the National Academy of Sciences of the United States of America1993
Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Immunology · 2012Pooled it
- CD45 as a multifunctional target in immune regulation and therapeutic delivery.Journal of translational medicine · 2026Review
- Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy.Science translational medicine · 2023Article
- Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse.bioRxiv : the preprint server for biology · 2023Article
- Luxeptinib interferes with LYN-mediated activation of SYK and modulates BCR signaling in lymphoma.PloS one · 2023Article
- How the Discovery of the CD4/CD8-p56Frontiers in cell and developmental biology · 2021Review
- Transforming growth factor β (TGF-β) receptor signaling regulates kinase networks and phosphatidylinositol metabolism during T-cell activation.The Journal of biological chemistry · 2020Article
- Protein tyrosine phosphatases as potential therapeutic targets.Acta pharmacologica Sinica · 2014Review
- Cluster of differentiation 45 activation is crucial in interleukin-10-dependent tumor-associated dendritic cell differentiation.Oncology letters · 2014Article
- Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.Current allergy and asthma reports · 2012Review
- Protein tyrosine phosphatases in lymphocyte activation and autoimmunity.Nature immunology · 2012Review
- A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.The Journal of biological chemistry · 2011Article
- T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Th1 and Th2 cells form morphologically distinct immunological synapses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Increased susceptibility to apoptosis in CD45(+) myeloma cells accompanied by the increased expression of VDAC1.Oncogene · 2006Article
- Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.Molecular and cellular biology · 2005Article
- Src-family kinases in B-cell development and signaling.Oncogene · 2004Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Stimulation of tyrosine phosphorylation is an early and important event in antigen-induced T-cell activation. T-cell clones deficient in expression of CD45, a transmembrane protein-tyrosine-phosphatase (protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48), are impaired in their ability to respond to either antigen or T-cell receptor cross-linking. Analysis of the CD45-deficient CD8+ T-cell clone L3M-93 demonstrates that the Src family members p56lck and p59fyn show increased immunoreactivity with anti-phosphotyrosine antibody and exhibit decreased kinase activity. The site of increased tyrosine phosphorylation in Src family members was identified by comparison of cyanogen bromide peptide maps. Phosphorylation of the C-terminal phosphopeptide, containing the negative regulatory site of tyrosine phosphorylation, from the CD45-deficient cells was increased 8-fold for p56lck and 2-fold for p59fyn. These data suggest that CD45 dephosphorylates the negative regulatory site of multiple Src family members in the cytotoxic T-lymphocyte clone L3 and show a correlation between the ability to respond efficiently to antigen and the dephosphorylation of Src family members by CD45.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.