ArticleProceedings of the National Academy of Sciences of the United States of America1993
Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 137 citations in OpenAlex.
- Meiotic Recombination May Be Initiated by Copy Choice During DNA Synthesis Rather than Break/Join Mechanism.International journal of molecular sciences · 2025Review
- A human cell-based reporter detects microhomology-mediated end joining.Mutation research · 2012Article
- Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.PLoS genetics · 2010Article
- Ionizing radiation induces microhomology-mediated end joining in trans in yeast and mammalian cells.Radiation research · 2009Article
- Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.Nucleic acids research · 2008Article
- Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks.Nucleic acids research · 2008Article
- Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae.Nucleic acids research · 2007Article
- Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome.Nucleic acids research · 2002Article
- Article
- High frequency of deletions at the hypoxanthine-guanine phosphoribosyltransferase locus in an ataxia-telangiectasia lymphoblastoid cell line irradiated with gamma-rays.Japanese journal of cancer research : Gann · 2001Article
- Heat effects on DNA repair after ionising radiation: hyperthermia commonly increases the number of non-repaired double-strand breaks and structural rearrangements.Nucleic acids research · 2001Article
- Homologous and nonhomologous recombination resulting in deletion: effects of p53 status, microhomology, and repetitive DNA length and orientation.Molecular and cellular biology · 2000Article
- X-ray-induced mutations in mouse embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Molecular origin of the mosaic sequence arrangements of higher primate alpha-globin duplication units.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Apparent and real recombination frequencies in multicopy plasmids: the need for a novel approach in frequency determination.Journal of bacteriology · 1997Article
- Copy-choice recombination mediated by DNA polymerase III holoenzyme from Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Instability of long inverted repeats within mouse transgenes.The EMBO journal · 1996Article
- The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination.Genetics · 1996Article
- High-frequency illegitimate integration of transfected DNA at preintegrated target sites in a mammalian genome.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HPRT gene mutants were isolated from untreated and x-irradiated cultures of primary human fibroblasts, and mutants carrying large deletions were identified. The breakpoints of the deletions were mapped by methods based on the polymerase chain reaction, and the deletion junctions of four different mutants were sequenced. Alu repeats were associated with one end of three of these junctions, but in each case repeat sequences were not found at the other end. Sequence features found at the deletion breakpoints included in particular short direct and inverted repeats, which may mispair to promote illegitimate recombination. One mutant had additional bases inserted at the deletion junction; these bases formed a direct repeat with a sequence immediately adjacent to the junction, suggesting a mechanism of templated repair of broken DNA in deletion formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.