ArticleThe Journal of clinical investigation1993
Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used.Frontiers in immunology · 2018Article
- Mapping an epitope in EBNA-1 that is recognized by monoclonal antibodies to EBNA-1 that cross-react with dsDNA.Immunity, inflammation and disease · 2016Article
- Article
- Deficiency in activation-induced cytidine deaminase promotes systemic autoimmunity in lpr mice on a C57BL/6 background.Clinical and experimental immunology · 2010Article
- Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Immunoglobulin VH-gene usage of autoantibodies in mercuric chloride-induced membranous glomerulopathy in the rat.Immunology · 2001Article
- CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus.The Journal of clinical investigation · 2000Article
- Idiotype usage by polyclonally activated B cells in experimental autoimmunity and infection.Clinical and experimental immunology · 1999Article
- B cells and autoantibodies in the pathogenesis of lupus nephritis.Immunologic research · 1998Review
- Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity.The Journal of clinical investigation · 1996Article
- Sequence analysis of the germ-line VH gene corresponding to a nephritogenic antibody in MRL/lpr lupus mice.Clinical and experimental immunology · 1995Article
- Human autoantibody recognition of DNA.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Structural properties of a subset of nephritogenic anti-DNA antibodies.Immunologic research · 1994Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
To examine the influence of variable region sequences on the capacity of individual lupus autoantibodies (autoAb) to form glomerular immune deposits, the complete VH and VL region sequences of three anti-DNA mAb that produced morphologically similar immune deposits after administration to normal mice were determined. The Ig were independently derived from 1-mo-old (H238, IgM), 3-mo-old (H8, IgG2a), and 6-mo-old (H161, IgG3) MRL-lpr/lpr mice, and they all produced subendothelial and mesangial immune deposits after passive transfer to normal mice. In addition, H238 and H161 produced granular deposits in small extraglomerular vessels. The mAb had nearly identical VH gene sequences; H8 differed from H238 and H161 by a single nucleotide in FR1 that resulted in a histidine for glutamine substitution. This VH gene sequence was also > 99% homologous to another anti-DNA Ab (termed H241), that we previously reported to produce glomerular immune deposits in a similar morphologic pattern. H161 and H238 were encoded by DFL16 and JH2 genes, whereas H8 was encoded by a JH4 gene. Different Vk family genes were used to encode the three mAb, however H161 and H238 both used a Jk5 gene. The results indicate that an identical or highly related VH gene is used to encode a subgroup of murine lupus autoAb that share immune deposit forming properties. Furthermore, they raise the possibility that amino acid residues independent from those encoded by VH genes may be influential in immune deposit formation at extraglomerular sites.
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