ArticleThe Journal of cell biology1993
BIMA, a TPR-containing protein required for mitosis, localizes to the spindle pole body in Aspergillus nidulans.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- The MYB-like protein MylA contributes to conidiogenesis and conidial germination in Aspergillus nidulans.Communications biology · 2024Article
- Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase.The Journal of cell biology · 2010Article
- Cdk1 phosphorylation sites on Cdc27 are required for correct chromosomal localisation and APC/C function in syncytial Drosophila embryos.Journal of cell science · 2007Article
- Cytoplasmic dynein's mitotic spindle pole localization requires a functional anaphase-promoting complex, gamma-tubulin, and NUDF/LIS1 in Aspergillus nidulans.Molecular biology of the cell · 2005Article
- Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss.Antimicrobial agents and chemotherapy · 2004Article
- The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit.The Plant cell · 2003Article
- Identification of essential genes in the human fungal pathogen Aspergillus fumigatus by transposon mutagenesis.Eukaryotic cell · 2003Article
- Regulation of the anaphase-promoting complex/cyclosome by bimAAPC3 and proteolysis of NIMA.Molecular biology of the cell · 1998Article
- A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans.The Journal of cell biology · 1998Article
- Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.The EMBO journal · 1998Article
- A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells.Molecular and cellular biology · 1998Article
- Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cell cycle regulation in Aspergillus by two protein kinases.The Biochemical journal · 1996Review
- Characterization and localization of the cytoplasmic dynein heavy chain in Aspergillus nidulans.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.Genetics · 1995Article
- NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration.Molecular biology of the cell · 1995Article
- Premature chromatin condensation upon accumulation of NIMA.The EMBO journal · 1994Article
- Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis.The EMBO journal · 1994Article
- A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.The EMBO journal · 1994Article
- DBF8, an essential gene required for efficient chromosome segregation in Saccharomyces cerevisiae.Molecular and cellular biology · 1994Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The Aspergillus nidulans bimA gene is required for mitosis. Loss of function mutations in bimA cause cells to arrest growth with condensed chromatin and a short, metaphaselike mitotic spindle. bimA is a member of a gene family defined by a repeated motif called the Tetratrico Peptide Repeat (TPR), which is found in genes from bacteria, yeast and insects. Several yeast TPR genes are also required for mitosis, including Saccharomyces cerevisiae CDC27 and Schizosaccharomyces pombe nuc2+, which appear to be functional homologs of bimA. We have developed antisera specific to the bimA protein (BIMA) and have characterized BIMA by western blot and immunocytochemical analyses. BIMA is heterogeneous in apparent molecular weight, consisting of a major 90-kD species and at least two minor species of approximately 105 kD. The results of BIMA localization by immunofluorescence microscopy depend on the level of BIMA expression. Overexpression of BIMA, which had no deleterious affect on growth or mitosis, resulted in localization of BIMA on or throughout most nuclei. Nuclear staining was granular, and overlapped but was not completely coincident with DNA staining by DAPI. In contrast, when expressed at normal levels, BIMA colocalized with the spindle pole body (SPB). BIMA localized to the SPB in a cell cycle independent manner. These results show that BIMA is either associated with or is a component of the SPB, and they suggest that BIMA functions at the spindle poles to promote the onset of anaphase.
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