ArticleHuman genetics1993
Chromosomal analysis of unfertilized human oocytes prepared by a gradual fixation-air drying method.
Article in Human genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 150 citations in OpenAlex.
- Sperm and Oocyte Chromosomal Abnormalities.Biomolecules · 2023Review
- Epigenetic Dysregulation Observed in Monosomy Blastocysts Further Compromises Developmental Potential.PloS one · 2016Article
- Preimplantation genetic screening (PGS) with Comparative genomic hybridization (CGH) following day 3 single cell blastomere biopsy markedly improves IVF outcomes while lowering multiple pregnancies and miscarriages.Journal of assisted reproduction and genetics · 2013Article
- A study of meiotic segregation in a fertile human population following ovarian stimulation with recombinant FSH-LH.Journal of assisted reproduction and genetics · 2013Article
- Article
- Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.Molecular human reproduction · 2008Article
- Human oocyte chromosome analysis: complicated cases and major pitfalls.Journal of genetics · 2008Article
- First-meiotic-division nondisjunction in human oocytes.American journal of human genetics · 1997Article
- Human female meiosis: new insights into an error-prone process.American journal of human genetics · 1997Review
- Association between nondisjunction and maternal age in meiosis-II human oocytes.American journal of human genetics · 1996Article
- A fluorescent in situ hybridization analysis of X chromosome pairing in early human female meiosis.Human genetics · 1994Article
- Cytogenetic analysis of human oocytes parthenogenetically activated by puromycin.Journal of assisted reproduction and genetics · 1994Article
- Chromosomal analysis of unfertilized human oocytes prepared by a gradual fixation-air drying method.Human genetics · 1993Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two hundred and sixty-five unfertilized human metaphase II (M II) oocytes from an in vitro fertilization program were studied cytogenetically using our chromosomal technique, a gradual fixation-air drying method. Of the 265 oocytes, 185 (70%) were successfully karyotyped. There were 21 aneuploids (11.4%) consisting of 8 hyperhaploids (4.3%), 11 hypohaploids (5.9%) and 2 complex cases (1.1%). There were also 9 structural anomalies (4.9%) and 18 diploids (9.7%). In aneuploidy, the loss or gain of dyads (so-called nondisjunction) occurred more frequently than the loss or gain of monads (so-called predivision). The frequency of abnormally behaved chromosomes (segregation errors) due to nondisjunction, anaphase lag and predivision was studied among the seven chromosomal groups (A-G) and compared with the frequency expected from an equal probability of segregation errors in each of the 23 chromosomes. The observed frequency was somewhat higher than the expected frequency in groups E and G but the difference was not statistically significant in either group. These results were discussed in relation to previous studies on human M II oocyte chromosomes.
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