ArticleThe EMBO journal1993
Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 325 citations in OpenAlex.
- Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: A Novel Approach for Anti-Inflammatory Wound Dressings.Pharmaceutics · 2024Article
- Effects of Group Size on Behavior, Reproduction, and mRNA Expression in Brains of Brandt's Voles.Brain sciences · 2023Article
- Molecular Derangements and the Diagnosis of ACTH-Dependent Cushing's Syndrome.Endocrine reviews · 2022Review
- Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)physiology: A Primer.Cells · 2022Review
- Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics.International review of neurobiology · 2021Article
- Targeting Corticotroph HDAC and PI3-Kinase in Cushing Disease.The Journal of clinical endocrinology and metabolism · 2021Article
- Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription.Cells · 2020Review
- Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis.Frontiers in psychiatry · 2020Review
- Glucocorticoid Receptor Stimulation Resulting from Early Life Stress Affects Expression of DNA Methyltransferases in Rat Prefrontal Cortex.Journal of molecular neuroscience : MN · 2019Article
- POMC: The Physiological Power of Hormone Processing.Physiological reviews · 2018Review
- Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program.Molecular cell · 2018Article
- Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages.PloS one · 2017Article
- Article
- Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice.Endocrinology · 2016Article
- Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.The Journal of clinical endocrinology and metabolism · 2016Article
- ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors.Genome research · 2015Article
- Kinetically-defined component actions in gene repression.PLoS computational biology · 2015Article
- Developmental programming of hypothalamic neuronal circuits: impact on energy balance control.Frontiers in neuroscience · 2015Review
- Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice.Frontiers in neuroendocrinology · 2015Review
- VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.EMBO molecular medicine · 2013Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies defined a DNA element necessary for glucocorticoid repression of the pro-opiomelanocortin (POMC) gene. The glucocorticoid receptor (GR) binds this negative glucocorticoid response element (nGRE) with an in vitro affinity similar to that of GR for positive GREs. However, whereas GR binds GREs as homodimers, a novel GR complex which forms with nGRE appears to contain three GR molecules. Biochemical characterization of this complex as well as equilibrium binding studies suggest that it is formed by sequential binding of a GR homodimer followed by binding of a GR monomer on the opposite side of the double helix. The DNA-binding domain (DBD) of GR is sufficient for differential binding of GRE and nGRE, as bacterially-expressed DBD formed unique nGRE complexes that contain three GR polypeptides. Thus, the POMC nGRE provides the first example of an interaction between GR and DNA in which GR binds otherwise than as a homodimer. Despite its high affinity for GR, the nGRE differs significantly from GREs in that it does not activate transcription in any context. As the nGRE appears insufficient on its own to confer hormone responsiveness, other POMC promoter elements are likely to be required to mediate glucocorticoid repression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.