ArticleBritish journal of pharmacology1993
Glucocorticoid-and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo.
Article in British journal of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 115 citations in OpenAlex.
- Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome. The Phospholipase A2 Study Group.The Clinical investigator · 1994Trial
- Article
- Analysis of human lung mast cells by single cell RNA sequencing.Frontiers in immunology · 2023Article
- The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons.Cell & bioscience · 2021Article
- Endogenous Annexin-A1 Negatively Regulates Mast Cell-Mediated Allergic Reactions.Frontiers in pharmacology · 2019Article
- Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?The EPMA journal · 2013Article
- Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1.PloS one · 2013Article
- Glucocorticoid-stimulated, transcription-independent release of annexin A1 by cochlear Hensen cells.British journal of pharmacology · 2009Article
- Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics.British journal of pharmacology · 2009Review
- Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.Biochemical pharmacology · 2009Article
- Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.British journal of pharmacology · 2008Review
- Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3.The Journal of biological chemistry · 2007Article
- Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages.British journal of pharmacology · 2004Article
- Annexin 1 localisation in tissue eosinophils as detected by electron microscopy.Mediators of inflammation · 2002Article
- Dexamethasone induces the secretion of annexin I in immature lymphoblastic cells by a calcium-dependent mechanism.Molecular and cellular biochemistry · 2002Article
- Glucocorticoids and TGF-beta1 synergize in augmenting fibroblast mediated contraction of collagen gels.Inflammation · 2001Article
- Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression.The American journal of pathology · 2001Article
- The inhibitory effect of dexamethasone on lymphocyte adhesion molecule expression and intercellular aggregation is not mediated by lipocortin 1.Clinical and experimental immunology · 1999Article
- Differential modulation of annexin I binding sites on monocytes and neutrophils.Mediators of inflammation · 1999Article
- Biochemical characterization of a glucocorticoid-induced membrane protein (RM3/1) in human monocytes and its application as model system for ranking glucocorticoid potency.Pharmaceutical research · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1. We have studied the occurrence, distribution and disposition of lipocortins (annexins) 1, 2 and 5 in mixed peritoneal leucocytes obtained from rats in which glucocorticoid levels were altered by adrenalectomy, administration of the glucocorticoid antagonist, RU486, or by injection of dexamethasone or hydrocortisone, as well as from rats in which the peritoneal cells were elicited by inflammatory stimuli. 2. In cells obtained from untreated rats with an intact adrenal cortex, lipocortins 1, 2 and 5 were readily detectable: the majority of each of the proteins was apparently located intracellularly with much smaller amounts in the membrane. Lipocortin 1 and to a lesser extent lipocortin 5 were also seen in a Ca(2+)-dependent association with the external plasma membrane. Following administration of RU486 (2 x 20 mg kg-1) the amounts of lipocortin 1 and 2 in cells were greatly reduced. Conversely, injection of hydrocortisone (1 mg kg-1) or dexamethasone (0.08 mg kg-1) caused an increase in the amount of lipocortin 1 and 2 in peritoneal cells within 30 min. Lipocortin 5 was unchanged by any manipulation of glucocorticoid levels. 3. Lipocortins 1 and 2 were elevated in both intracellular and membrane-associated fractions of macrophages elicited by intraperitoneal injection in inflammogens. This phenomenon also occurred in adrenalectomized animals. 4. Our data indicate that glucocorticoids control the synthesis of some members of the lipocortin family in rat mixed peritoneal cells but also suggest the existence of a separate system for controlling the generation of this protein. The significance of these observations is considered in relation to the mechanism of glucocorticoid hormone action on eicosanoid production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.