ArticleBritish journal of cancer1993
Humoral mediation for cachexia in tumour-bearing rats.
Article in British journal of cancer, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 119 citations in OpenAlex.
- Review
- Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Biomarkers for Cancer Cachexia: A Mini Review.International journal of molecular sciences · 2021Review
- Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Evidence of Blood and Muscle Redox Status Imbalance in Experimentally Induced Renal Insufficiency in a Rabbit Model.Oxidative medicine and cellular longevity · 2019Article
- Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effects of celecoxib and ibuprofen on metabolic disorders induced by Walker-256 tumor in rats.Molecular and cellular biochemistry · 2015Article
- Decreased response to cAMP in the glucose and glycogen catabolism in perfused livers of Walker-256 tumor-bearing rats.Molecular and cellular biochemistry · 2012Article
- Muscle wasting in animal models of severe illness.International journal of experimental pathology · 2012Review
- l-carnitine and cancer cachexia: Clinical and experimental aspects.Journal of cachexia, sarcopenia and muscle · 2011Article
- TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2005Article
- Increased muscle proteasome activity correlates with disease severity in gastric cancer patients.Annals of surgery · 2003Article
- Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia.British journal of cancer · 2001Article
- Day-night pattern of energy expenditure and body temperature in cachectic tumour-bearing rats.British journal of cancer · 2000Article
- Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats.British journal of cancer · 2000Article
- [Pathophysiology of catabolism in undernurished elderly patients].Zeitschrift fur Gerontologie und Geriatrie · 1999Review
- Lipid metabolism in rats bearing the Yoshida AH-130 ascites hepatoma.Molecular and cellular biochemistry · 1996Article
- Are cytokines possible mediators of cancer cachexia?Surgery today · 1996Review
- Perturbations of triglycerides but not of cholesterol metabolism are prevented by anti-tumour necrosis factor treatment in rats bearing an ascites hepatoma (Yoshida AH-130).British journal of cancer · 1995Article
- Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early and severe loss of body weight associated with pronounced tissue changes developed in rats transplanted with a fast-growing ascites hepatoma (Yoshida AH-130). The protein content showed an early and marked fall in the skeletal muscle, while in the liver it transiently increased 4 days after implantation then declined to values lower than in control animals. Protein loss in gastrocnemius muscle and liver resulted mainly from enhancement of protein catabolism (Tessitore L. et al., Biochem. J., 241: 153-158, 1987). In contrast to the tumour-bearing rats, in the pair-fed animals the initial body weight was maintained, while the protein mass decreased sharply in the liver and moderately in the gastrocnemius muscle. In host animals total plasma protein decreased during the period of tumour growth, while both triglycerides and total cholesterol markedly increased. Glucose remained unchanged even when overt cachexia had developed. The total free amino acid concentration in the plasma of tumour-bearing rats decreased slightly by day 4 and returned to values close to those of controls in the late stages of tumour growth. By contrast, in the pair-fed controls the plasma levels of triglycerides and particularly of total free amino acids and glucose decreased over the whole experimental period, whereas total protein and cholesterol were unchanged. Marked perturbations in the hormonal homeostasis developed early after tumour transplantation. The plasma levels of glucagon, corticosterone and catecholamines rose sharply, while those of insulin and thyroid hormones decreased. Furthermore, high plasma concentrations of prostaglandin E2 (PGE2) and tumour necrosis factor (TNF) were observed over the whole experimental period. IL-1-like activity, TNF and PGE2 were released in vitro from AH-130 cells. These data suggest that the systemic effects of AH-130 tumour on the host rat reflected the interplay of a complex network of factors, including classical hormones and cytokines, all of which likely concur in enhancing tissue protein catabolism.
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