ArticleThe Journal of cell biology1993
Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 148 citations in OpenAlex.
- STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.Journal of cellular and molecular medicine · 2022Article
- Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils.Journal of immunology research · 2017Article
- LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner.Journal of neuroinflammation · 2012Article
- Anti-alpha4beta1 integrin antibody induces receptor internalization and does not impair the function of circulating neutrophilic leukocytes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Short-term heat exposure inhibits inflammation by abrogating recruitment of and nuclear factor-{kappa}B activation in neutrophils exposed to chemotactic cytokines.The American journal of pathology · 2008Article
- Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration.American journal of respiratory and critical care medicine · 2007Article
- Role of protein tyrosine kinase p53/56lyn in diminished lipopolysaccharide priming of formylmethionylleucyl- phenylalanine-induced superoxide production in human newborn neutrophils.Infection and immunity · 2004Article
- A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release.British journal of pharmacology · 2004Article
- Environment-dependent down-modulation of CD45 cell surface expression on polymorphonuclear cells.Journal of clinical laboratory analysis · 2004Article
- PMN transendothelial migration decreases nuclear NFkappaB in IL-1beta-activated endothelial cells: role of PECAM-1.The Journal of cell biology · 2003Article
- Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation.The Journal of experimental medicine · 2003Article
- Fibrinogen is degraded and internalized during incubation with neutrophils, and fibrinogen products localize to electron lucent vesicles.The Biochemical journal · 2002Article
- Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.The Journal of clinical investigation · 1999Article
- Src-family kinase-p53/ Lyn p56 plays an important role in TNF-alpha-stimulated production of O2- by human neutrophils adherent to fibrinogen.Inflammation · 1999Article
- The effect of flow on the neutrophil-mediated Ca2+ responses in human vascular endothelial cells stimulated by endotoxin.Surgery today · 1999Article
- Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Interleukin-2 induces beta2-integrin-dependent signal transduction involving the focal adhesion kinase-related protein B (fakB).Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.The Biochemical journal · 1998Article
- Insulin induces tyrosine dephosphorylation of a 92 kDA protein in suspended monocytes.Journal of endocrinological investigation · 1998Article
- Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors.British journal of pharmacology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human neutrophils (PMN) respond to tumor necrosis factor (TNF) by releasing their granules, reorganizing their cytoskeleton, and massively secreting hydrogen peroxide. This response is dependent on adhesion to extracellular matrix proteins and expression of CD11b/CD18 integrins (Nathan, C., S. Srimal, C. Farber, E. Sanchez, L. Kabbash, A. Asch, J. Gailit, and S. D. Wright. 1989. J. Cell Biol. 109:1341-1349). We investigated the role of tyrosine phosphorylation in the response of PMN to TNF. PMN adherent to protein-coated surfaces but not suspended PMN showed tyrosine phosphorylation of several proteins (approximately 150, approximately 115, approximately 75, and approximately 65 kD) in response to TNF. Tyrosine phosphorylation was evident 5 min after addition of TNF and lasted at least 2 h. The tyrosine kinase inhibitors K252a, genistein and ST638 suppressed tyrosine phosphorylation and blocked hydrogen peroxide production in a reversible manner at low concentrations. Tyrosine kinase inhibitors also blocked the spreading of PMN in response to TNF. Dihydrocytochalasin B did not inhibit tyrosine phosphorylation, but in its presence phosphorylation was rapidly reversed. By immunocytochemistry, the majority of tyrosine phosphoproteins were localized to focal adhesions. Thus TNF-induced tyrosine phosphorylation depends on adhesion of PMN to extracellular matrix proteins, and participates in the transduction of the signals that direct the cells to spread on a biological surface and undergo a respiratory burst.
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