ArticleThe Journal of cell biology1993
Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 162 citations in OpenAlex.
- Protein Quality Control at the Sarcomere: Titin Protection and Turnover and Implications for Disease Development.Frontiers in physiology · 2022Review
- Small heat-shock proteins and their role in mechanical stress.Cell stress & chaperones · 2020Review
- Small heat shock protein speciation: novel non-canonical 44 kDa HspB5-related protein species in rat and human tissues.Cell stress & chaperones · 2018Article
- The small heat shock protein HSPB1 protects mice from sepsis.Scientific reports · 2018Article
- Crystallins and neuroinflammation: The glial side of the story.Biochimica et biophysica acta · 2016Article
- Heat shock protein concentration and clarity of porcine lenses incubated at elevated temperatures.Molecular vision · 2016Article
- Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis.Cellular and molecular life sciences : CMLS · 2015Review
- HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock.Molecular biology of the cell · 2014Article
- Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.The Journal of cell biology · 2014Article
- A novel approach to collecting satellite cells from adult skeletal muscles on the basis of their stress tolerance.Stem cells translational medicine · 2013Article
- Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis.Carcinogenesis · 2010Article
- Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.Human molecular genetics · 2009Article
- Expression and regulation of alphaB-crystallin in the kidney in vivo and in vitro.Pflugers Archiv : European journal of physiology · 2006Article
- Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.Cell stress & chaperones · 2005Article
- Small heat shock proteins from extremophiles: a review.Extremophiles : life under extreme conditions · 2004Review
- Distribution, phosphorylation, and activities of Hsp25 in heat-stressed H9c2 myoblasts: a functional link to cytoprotection.Cell stress & chaperones · 2002Article
- Regulation and mechanism of action of the small heat shock protein from the hyperthermophilic archaeon Pyrococcus furiosus.Journal of bacteriology · 2001Article
- Perinatal expression of heat-shock protein 27 in brain regions and nonneural tissues of the piglet.Journal of molecular neuroscience : MN · 2000Article
- The distribution of heat shock proteins in the nervous system of the unstressed mouse embryo suggests a role in neuronal and non-neuronal differentiation.Cell stress & chaperones · 2000Article
- Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress induces the synthesis of several large and small heat shock proteins (hsp's). Two related small hsp's, hsp25 and alpha B crystallin exist in mice. alpha B crystallin is an abundant protein in several tissues even in the absence of stress. Particularly high amounts accumulate in the eye lens. Here we show that hsp25 is likewise constitutively expressed in many normal adult tissues. In the absence of stress the protein is most abundant in the eye lens, heart, stomach, colon, lung, and bladder. The stress-independent expression pattern of the two small hsp's is distinct. In several tissues the amount of hsp25 exceeds that accumulating in NIH 3T3 fibroblasts in response to heat stress. hsp25, like alpha B crystallin, exists in a highly aggregated form in the eye lens. The expression of hsp25 and alpha B crystallin in normal tissues suggests an essential, but distinct function of the two related proteins under standard physiological conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.