ArticleMolecular and cellular biology1993
Increased UV resistance of a xeroderma pigmentosum revertant cell line is correlated with selective repair of the transcribed strand of an expressed gene.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- PCR-based methods for detecting DNA damage and its repair at the sub-gene and single nucleotide levels in cells.Molecular biotechnology · 2002Article
- Regulation of the ribonucleotide reductase small subunit gene by DNA-damaging agents in Dictyostelium discoideum.Nucleic acids research · 1999Article
- Induction of the SOS response increases the efficiency of global nucleotide excision repair of cyclobutane pyrimidine dimers, but not 6-4 photoproducts, in UV-irradiated Escherichia coli.Journal of bacteriology · 1998Article
- The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein.The Biochemical journal · 1997Review
- Role of transcription-coupled DNA repair in susceptibility to environmental carcinogenesis.Environmental health perspectives · 1996Review
- Repair mechanisms of UV-induced DNA damage in soybean chloroplasts.Plant molecular biology · 1995Article
- Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells.Nucleic acids research · 1994Article
- A strand bias occurs in point mutations associated with variant surface glycoprotein gene conversion in Trypanosoma rhodesiense.Molecular and cellular biology · 1994Article
- Repair by human cell extracts of single (6-4) and cyclobutane thymine-thymine photoproducts in DNA.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Human ERCC5 cDNA-cosmid complementation for excision repair and bipartite amino acid domains conserved with RAD proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A UV-resistant revertant (XP129) of a xeroderma pigmentosum group A cell line has been reported to be totally deficient in repair of cyclobutane pyrimidine dimers (CPDs) but proficient in repair of 6-4 photoproducts. This finding has been interpreted to mean that CPDs play no role in cell killing by UV. We have analyzed the fine structure of repair of CPDs in the dihydrofolate reductase gene in the revertant. In this essential, active gene, we observe that repair of the transcribed strand is as efficient as that in normal, repair-proficient human cells, but repair of the nontranscribed strand is not. Within 4 h after UV at 7.5 J/m2, over 50% of the CPDs were removed, and by 8 h, 80% of the CPDs were removed. In contrast, there was essentially no removal from the nontranscribed strand even by 24 h. Our results demonstrate that overall repair measurements can be misleading, and they support the hypothesis that removal of CPDs from the transcribed strands of expressed genes is essential for UV resistance.
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