ArticleMolecular and cellular biology1993
Transcriptional activation by simian virus 40 large T antigen: interactions with multiple components of the transcription complex.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 113 citations in OpenAlex.
- Association Between Simian Virus 40 and Human Tumors.Frontiers in oncology · 2019Review
- Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity.The Journal of general virology · 2010Article
- Simian virus 40 activates ATR-Delta p53 signaling to override cell cycle and DNA replication control.Journal of virology · 2010Article
- Enhancement of enteric adenovirus cultivation by viral transactivator proteins.Applied and environmental microbiology · 2010Article
- Article
- Simian virus 40 large T overcomes p300 repression of c-Myc.Virology · 2008Article
- Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR.RNA (New York, N.Y.) · 2007Article
- p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation.RNA (New York, N.Y.) · 2006Article
- SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Oncogene · 2005Review
- Activation of CREB/ATF sites by polyomavirus large T antigen.Journal of virology · 2005Article
- Cell type-specific replication of simian virus 40 conferred by hormone response elements in the late promoter.Journal of virology · 2002Article
- Simian virus 40 large T-antigen, but not small T-antigen, trans-activates the human cytomegalovirus major immediate early promoter.Virus genes · 2001Article
- A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants.The EMBO journal · 2000Article
- J domain-independent regulation of the Rb family by polyomavirus large T antigen.Journal of virology · 2000Article
- Different functions are required for initiation and maintenance of immortalization of rat embryo fibroblasts by SV40 large T antigen.Oncogene · 1999Article
- Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen.Journal of virology · 1999Article
- New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen.Molecular and cellular biology · 1999Article
- The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1/Oct6/SCIP.Molecular and cellular biology · 1999Article
- Chromatin structure of the simian virus 40 late promoter: a deletional analysis.Journal of virology · 1999Article
- Interaction of the transcription factor TFIID with simian virus 40 (SV40) large T antigen interferes with replication of SV40 DNA in vitro.Journal of virology · 1999Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Simian virus 40 (SV40) large T antigen is a potent transcriptional activator of both viral and cellular promoters. Within the SV40 late promoter, a specific upstream element necessary for T-antigen transcriptional activation is the binding site for transcription-enhancing factor 1 (TEF-1). The promoter structure necessary for T-antigen-mediated transcriptional activation appears to be simple. For example, a promoter consisting of upstream TEF-1 binding sites (or other factor-binding sites) and a downstream TATA or initiator element is efficiently activated. It has been demonstrated that transcriptional activation by T antigen does not require direct binding to the DNA; thus, the most direct effect that T antigen could have on these simple promoters would be through protein-protein interactions with either upstream-bound transcription factors, the basal transcription complex, or both. To determine whether such interactions occur, full-length T antigen or segments of it was fused to the glutathione-binding site (GST fusions) or to the Gal4 DNA-binding domain (amino acids 1 to 147) (Gal4 fusions). With the GST fusions, it was found that TEF-1 and the TATA-binding protein (TBP) bound different regions of T antigen. A GST fusion containing amino acids 5 to 172 (region T1) efficiently bound TBP. TEF-1 bound neither region T1 nor a region between amino acids 168 and 373 (region T2); however, it bound efficiently to the combined region (T5) containing amino acids 5 to 383.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.